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Rabbit Anti-BMPR2 Polyclonal Antibody#abs131483

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Description

Catalog-specification	Delivery time	USD price
abs131483-50ug	1-2 Weeks	201.0
abs131483-100ug	1-2 Weeks	301.0

Overview
catalog	abs131483
Description	Binding of ligands leads to the formation of a receptor complex that includes two transmembrane serine/threonine kinases of type II and two of type I. The type II receptors are responsible for phosphorylating and activating the type I receptors. Subsequently, the activated type I receptors undergo autophosphorylation and then interact with and activate SMAD transcriptional regulators. Please note that the generated content above is a rearrangement of the original information, ensuring its similarity.
Other names	The BMP type II receptor, also known as BMPR-2, BMPR-II, or BMPR2, is a bone morphogenetic protein receptor that plays a crucial role in cellular signaling pathways. Along with BMP type-2 receptor and BMP type-3 receptor, BMPR-2 is involved in the regulation of various cellular processes, including cell proliferation and differentiation, bone development, and cardiovascular function. BMPR-2 is a member of the serine threonine kinase family and acts as a type II activin receptor-like kinase. It is essential for the proper functioning of the pulmonary vasculature, as mutations in the BMPR2 gene have been associated with the development of pulmonary arterial hypertension. In addition, BMPR-2 has also been implicated in the pathogenesis of various types of cancer, as well as in the regulation of immune responses. Thus, understanding the mechanisms by which BMPR-2 functions can have significant implications in the development of new therapeutic strategies for a range of diseases.
Source	Rabbit
Specificity	Our BMPR2 Antibody is designed to recognize total BMPR2 protein levels in the body, indicating the presence of endogenous BMPR2. By detecting endogenous levels of total BMPR2, this antibody enables researchers to study the expression and localization of BMPR2 in various samples.
Species Reactivity	Human;Mouse;Rat;Monkey
Predictive reaction species	Rabbit;Xenopus;Sheep;Bovine;Horse;Chicken;
Antigen	BMPR2
Application	The recommended dilution range for WB is between 1:500 to 1:2000, while for IF/ICC it is 1:100 to 1:500. For ELISA, specifically using a peptide, the suggested dilution range is 1:20000 to 1:40000. It is important to follow these dilution ranges in order to achieve optimal results in these experiments.
Immunogen	A synthesized peptide derived from human BMPR2.
MW	115 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. A highly similar content can be created by rearranging the sentence structure to ensure accuracy of the original text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Tissue specificity	Highly expressed in heart and liver.
Celluar localization	Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q13873