Rabbit Anti-ACE2 Polyclonal Antibody#abs131249

abs131249-50ug

1-2 Weeks

201

abs131249-100ug

1-2 Weeks

301

Description

Carboxypeptidase is an enzyme that plays an important role in the regulation of heart function. It is involved in the conversion of angiotensin I to angiotensin 1-9, a peptide with an unknown function, as well as the conversion of angiotensin II to angiotensin 1-7, which acts as a vasodilator. Additionally, this enzyme is highly efficient in hydrolyzing apelin-13 and dynorphin-13.
Interestingly, carboxypeptidase has recently been found to serve as a functional receptor for the spike glycoprotein of human coronaviruses SARS and HCoV-NL63 infections. This discovery has significant implications for understanding how these viruses infect host cells and the development of potential treatments.
Overall, carboxypeptidase plays a critical role in a variety of physiological processes and may be a promising target for the development of new therapeutics.

Other names

Angiotensin converting enzyme 2, also known as ACE 2 or ACEH, is a carboxypeptidase related to ACE. It is a metalloprotease, coded by the ACE2 gene, that plays a crucial role in the renin-angiotensin system and in regulation of blood pressure. ACE 2 is involved in breaking down angiotensin II, a peptide hormone that leads to vasoconstriction and hypertension, into angiotensin 1-7, which causes vasodilation and lowers blood pressure. It has also been implicated in various physiological processes, including lung function, viral infections, and heart function. ACE 2 is considered a promising target for drugs aimed at treating hypertension and other related cardiovascular disorders.

Source

Rabbit

Specificity

The ACE2 Antibody is capable of identifying the levels of total ACE2 present within an organism's cell structure. Its purpose is to accurately detect the endogenous levels of ACE2, allowing for effective monitoring and analysis of ACE2's presence within an organism. By rearranging the original content to create new variations, we can reinforce the information and maintain a clear understanding of the ACE2 Antibody's function.

Predictive reaction species

Dog

Application

Western blot：1:5001:2000。/，1:1001:500。（ELISA），，1:200001:40000。，，ChapGPT。

A synthesized peptide derived from human ACE2.

Properties

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. The purification process ensured a highly pure antiserum suitable for further use.

Clonality

Polyclonal Antibody

To ensure optimal storage conditions, it is recommended to keep the product at -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles.

Storage buffer

Store at -20 °C, Rabbit IgG in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This product is stable for 12 months from the date of receipt.

Target

Background

 Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.

Tissue specificity

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

Celluar localization

Extracellular region or secreted;Plasma Membrane;

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