Rabbit Anti-HMGA2 Polyclonal Antibody#abs131140

abs131140-50ug

1-2 Weeks

201

abs131140-100ug

1-2 Weeks

301

Description

This molecule acts as a transcriptional regulator and plays a role in the regulation of the cell cycle by interacting with CCNA2.

Other names

High mobility group proteins (HMGP) are a family of nonhistone chromosomal architectural proteins that play important roles in various cellular processes, including transcriptional regulation, DNA repair, and chromatin remodeling. One member of this family is HMGA2, also known as High mobility group AT-hook protein 2 or Non histone chromosomal architectural protein HMGIC. This protein is primarily expressed in embryonic and fetal tissues, but is also found in adult tissues, including adipose tissue. HMGA2 has been linked to various pathophysiological conditions, including cancer and metabolic disorders, as well as regulating stem cell differentiation and aging. The role of HMGA2 in such processes may involve its ability to interact with various transcription factors and chromatin-modifying enzymes, thereby influencing gene expression. Further research on the dynamic regulation of HMGA2 expression and its downstream targets may shed light on its potential therapeutic implications.

Source

Rabbit

Specificity

The total HMGA2 protein at a natural level can be detected by the antibody.

Predictive reaction species

Sheep;Bovine;

Application

The recommended dilution for western blotting is 1:500-1:1000, while for ELISA using the peptide, it is suggested to dilute the sample at 1:20000-1:40000. It is important to note that these dilutions are based on the original text information and should be adhered to in order to achieve accurate and reliable results.

HMGA2aa. 6~10 (E-G-A-G-Q)，。HMGA2：6~10E、G、A、GQ。

Properties

1mg/ml

Purification

SulfoLink™ Coupling Resin was employed to carry out peptide affinity chromatography for the purification of the antiserum. Please provide a highly analogous statement by reorganizing the original information while maintaining its essence.

Clonality

Polyclonal Antibody

To ensure the quality of the product, it is recommended to store at a temperature of -20°C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this can affect its effectiveness.

Storage buffer

The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in a solution containing phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the antibody is guaranteed for a period of 12 months from the date of receipt.

Target

Background

This protein serves as a regulator of gene expression by controlling transcription. Its involvement in the regulation of the cell cycle, particularly through CCNA2, is significant. Furthermore, it plays a crucial role in the condensation of chromosomes during the meiotic G2/M transition in spermatocytes. Another important function of this protein is its participation in postnatal myogenesis, where it facilitates the activation of satellite cells. This protein's multifaceted roles highlight its importance in various biological processes.

Tissue specificity

Expressed predominantly during embryogenesis.

Celluar localization

Nucleus;

P52926