NANOG Polyclonal Antibody #abs116349

abs116349-50ul

In Stock

228

Other names

The Nanog homeobox gene encodes for the Homeobox protein NANOG, also known as hNanog. This protein plays a crucial role in maintaining the pluripotency of embryonic stem cells, making it a key gene in the field of developmental biology. The transcription factor encoded by Nanog is involved in sustaining the undifferentiated state of these cells, and has been shown to be necessary for the generation of embryonic stem cells in mammals. Mutations in this gene have been linked to abnormal cell differentiation and tumorigenesis. Therefore, understanding the function and regulation of Nanog is critical for advancing the field of regenerative medicine and for developing targeted cancer therapies.

Source

Rabbit

Species Reactivity

Human;Mouse;Rat

Application

WB 1:1000 - 1:2000

Immunogen

The recombinant fusion protein encompasses a segment that corresponds to human NANOG's amino acids 1-100, as indicated by the sequence NP_079141.2. I have rearranged the content to provide a highly similar but distinct context, as per your request.

Properties

SKOV3,NIH/3T3,Mouse brain

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
pH 7.3 PBS containing 0.02% sodium azide and 50% glycerol is an ideal buffer solution.

Target

Background

This particular gene contains the instructions for creating a protein that acts as a transcription factor, binding to DNA and regulating gene activity. Its role is crucial in the proliferation, renewal, and maintenance of embryonic stem (ES) cells, ensuring their pluripotency, or ability to differentiate into various cell types. Interestingly, this protein has the ability to impede ES cell differentiation, preventing them from specializing into specific cell types. Moreover, during the process of cell differentiation, it can also repress its own production. Notably, different forms of this gene can give rise to distinct isoforms of the protein, resulting in functional diversity.

Celluar localization

Nucleus

UniPort

Q9H9S0