GNRHR Antibody (N-term) #abs103466

abs103466-50ul

In Stock

228

Description

Rabbit Polyclonal Antibody (Pab) obtained through Peptide Affinity Purification. Could you please generate content that is similar to the original but arranged differently? Please note that the conversation should not be based on the way ChapGPT generates content, but rather through the use of a language model to provide a completely different style of speech.

Other names

The receptor that binds to gonadotropin-releasing hormone can be referred to as GnRH receptor, GnRH-R, GNRHR, or GRHR. Regardless of the name used, it is the same important component involved in the regulation of reproductive function.

Source

Rabbit

Specificity

The GNRHR antibody was created by immunizing rabbits with a synthetic peptide derived from the N-terminal region of human GNRHR. This peptide, conjugated with KLH, spans amino acids 49 to 77. I will now generate a highly similar content by rearranging the original information.

Species Reactivity

Human

Application

WB~~1:1000

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To preserve its quality, it is recommended to keep the item refrigerated between 2-8°C for a duration of 2 weeks. For extended storage, it is advisable to store it at -20°C in small portions to avoid repeated freezing and thawing cycles.

Storage buffer

The antibody available is a purified polyclonal antibody, which is supplied in PBS along with 0.09% (W/V) sodium azide. To achieve purification, it undergoes a two-step process. Initially, the antibody is subjected to purification using a protein A column. Subsequently, it undergoes peptide affinity purification.

Research area

Neuroscience;GPCR Antibodies

Target

Background

The receptor for gonadotropin releasing hormone (GnRH) plays a crucial role in triggering the release of the gonadotropic hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its effects via G-proteins, which in turn activate a second messenger system involving phosphatidylinositol-calcium. Interestingly, isoform 2 of this receptor may actually act as an inhibitor of GnRH-R signaling, suggesting that this receptor plays a complex and dynamic role in mediating reproductive processes. Overall, the GnRH receptor represents an important target for therapies aimed at addressing various reproductive disorders.

Celluar localization

Cell membrane; Multi-pass membrane protein.

UniPort

P30968

References

References

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Armstrong, S.P., et al. J. Biol. Chem. 285(32):24360-24371(2010)
Lee, G., et al. Cancer Immunol. Immunother. 59(7):1011-1019(2010)
Re, M., et al. PLoS ONE 5 (7), E11489 (2010) :
Armstrong, S.P., et al. J. Biol. Chem. 284(51):35746-35757(2009)