Rabbit Anti-CMKLR1 Polyclonal Antibody#abs131387
Please be informed that the mentioned price is solely for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. We encourage you to contact Vecent for accurate pricing details. This product is for research use only, not for use in...
Description
| Catalog-specification | Delivery time | USD price |
abs131387-50ug | 1-2 Weeks | 201.0 |
abs131387-100ug | 1-2 Weeks | 301.0 |
Please be informed that the mentioned price is solely for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. We encourage you to contact Vecent for accurate pricing details.
| Overview | |
catalog | abs131387 |
Description | This receptor is commonly known as an orphan receptor with potential chemical peptide properties. Its role in bone metabolism is being explored. Interestingly enough, it has been found to be a coreceptor for various SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, SIVSM62A) and even for one of the primary strains of HIV-1 (92UG024-2). |
| Other names | Chemokine-like receptor 1, also known as ChemerinR or CMKLR1, is a G-protein coupled receptor. It is also referred to as CHEMERINR or CHEMR23. Another name for this receptor is CML1_HUMAN. It is sometimes called DEZ or G protein coupled receptor DEZ. ChemR23 is an orphan G-protein coupled receptor, meaning that its ligands are still unidentified. It is also known as the resolvin E1 receptor or RVER1. |
| Source | Rabbit |
| Specificity | The detection of total CMKLR1 at the endogenous levels can be achieved using the CMKLR1 Antibody. It is capable of accurately identifying and quantifying the levels of CMKLR1 present in the biological sample. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Horse; |
| Antigen | CMKLR1 |
| Application | The recommended dilution for Western Blotting is between 1:500 and 1:2000. For Immunofluorescence/Immunocytochemistry, the suggested dilution is between 1:100 and 1:500. If you are performing an Enzyme-Linked Immunosorbent Assay (ELISA) using a peptide, the appropriate dilution range would be 1:20000 to 1:40000. It is important to follow these dilution guidelines to ensure accurate and reliable results in your experiments. |
| Immunogen | A synthesized peptide derived from human CMKLR1. |
| MW | 43 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™，。 |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). |
| Tissue specificity | Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. |
| Celluar localization | Plasma Membrane; |
| UniPort | Q99788 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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