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Rabbit Anti-LEG9 Polyclonal Antibody#abs131386

Description

Catalog-specification	Delivery time	USD price
abs131386-100ug	1-2 Weeks	301.0
abs131386-50ug	1-2 Weeks	201.0

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Overview
catalog	abs131386
Description	This protein binds to galactosides and has a strong affinity for the Forssman pentasaccharide. Its function in thymocyte-epithelial interactions is important for thymus biology, and it also inhibits cell proliferation. Furthermore, it can act as a ligand for HAVCR2/TIM3 and trigger T-helper type 1 lymphocyte (Th1) death. Interestingly, there is an isoform of this protein called Short that can act as a chemoattractant for eosinophils. Overall, this protein is involved in various cellular processes and has several important functions in the immune system.
Other names	Galectin-9, also known as Ecalectin or LGALS9, is a lectin protein that binds to beta-galactoside. It has a molecular weight of around 36 kDa. Other names for Galectin-9 include HOM HD 21, HUAT, Lectin galactoside binding soluble 9, LEG9_HUMAN, LGAL S9, LGALS 9, Lgals9, LGALS9A, MGC117375, MGC125973, MGC125974, Tumor antigen HOM-HD-21, and UAT. Galectin-9 is involved in various biological processes, including urate transport and channel regulation. Its structure and function make it a potential target for therapeutic interventions.
Source	Rabbit
Specificity	The LEG9 Antibody is capable of detecting the complete amount of LEG9 present within an organism. It has the ability to detect endogenous levels of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	LEG9
Application	，。： WB，1:500-1:2000C，IF1:100-1:500。，ELISA（）1:20000-1:40000。
Immunogen	A synthesized peptide derived from human LEG9.
MW	40 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. This method effectively removes impurities and isolates the desired substance for further use.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).
Tissue specificity	Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	O00182