Rabbit Anti-Kir6.2 Polyclonal Antibody#abs131385
Please note that the mentioned price is just for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.
Description
| Catalog-specification | Delivery time | USD price |
abs131385-100ug | 1-2 Weeks | 301.0 |
abs131385-50ug | 1-2 Weeks | 201.0 |
Please note that the mentioned price is just for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent.
| Overview | |
catalog | abs131385 |
Description | K(ATP) channels, which are sensitive to ATP, can be found in various types of cells, including endocrine cells, neurons, as well as both smooth and striated muscle. These channels are crucial in regulating insulin secretion and vascular tone, while also providing protection to neurons during times of metabolic stress. |
| Other names | The ATP sensitive inward rectifier potassium channel 11, also known as KCNJ11 or IRK11, is a beta cell inward rectifier subunit that plays an important role in regulating insulin secretion. The channel is composed of the Kir6.2 subunit, also known as Inward rectifier K(+) channel, which allows for the inward flow of potassium ions. Additionally, the channel is insensitive to external potassium ion concentration but is activated by intracellular ATP concentration. This aspect is significant in the regulation of insulin secretion and glucose homeostasis. The channel is linked with several conditions such as transient neonatal diabetes mellitus 3 and familial hyperinsulinemic hypoglycemia 2. Other names associated with the channel include PHHI, TNDM3, MGC133230, Beta cell inward rectifier subunit, BIR, HHF 2, HHF2, and IKATP. |
| Source | Rabbit |
| Specificity | The Kir6.2 Antibody is specifically designed to recognize and measure the natural levels of total Kir6.2 protein in biological samples. It offers a valuable tool for researchers to explore the expression and regulation of Kir6.2 and its functional significance. By detecting the endogenous levels of Kir6.2, this antibody provides a comprehensive understanding of the protein's involvement in various physiological and pathological processes. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Rabbit;Bovine;Horse |
| Antigen | Kir6.2 |
| Application | IHC: It is recommended to use a dilution range of 1:50 to 1:200 for WB (Western Blot) analysis. For IF (Immunofluorescence) experiments, a dilution of 1:100 to 1:500 is advised. When performing ELISA (Enzyme-Linked Immunosorbent Assay) with the peptide target, a dilution range of 1:20000 to 1:40000 is suggested. Please note that these dilutions are based on the original text information and should be optimized for specific experimental conditions. |
| Immunogen | A synthesized peptide derived from human Kir6.2. |
| MW | 44 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Utilizing SulfoLink™ Coupling Resin, purification of the antiserum was conducted through peptide affinity chromatography. To ensure high quality results, this method was chosen for its effectiveness in isolating and removing impurities from the final product. This purification process employs specific properties of the peptide, leading to greater specificity and purity in the final antiserum product. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. |
| Posttranslational modification | Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity. |
| Celluar localization | Cytosol;Endoplasmic reticulum;Endosome;Mitochondrion;Nucleus;Plasma Membrane; |
| UniPort | Q14654 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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