GPX1 Antibody (C-term) #abs111921

abs111921-50ul

In Stock

228

Description

An antibody that has been purified using peptide affinity techniques, and has been developed using rabbit polyclonal methodology is known as Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab). To create similar content, we can rephrase the above statement by stating that Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) is a type of antibody that has undergone purification using peptide affinity methods and is designed using rabbit polyclonal biology techniques.

Other names

The cellular enzyme known as glutathione peroxidase 1 is commonly referred to by several names, including GPx-1, GSHPx-1, and GPX1. This powerful antioxidant plays an important role in protecting cells from oxidative damage. As an essential component of the body's natural defense system, GPX1 eliminates harmful free radicals and reduces the risk of developing various diseases caused by oxidative stress. With its ability to maintain cellular health and vitality, GPX1 continues to be an important target of scientific research in the field of antioxidant therapy.

Source

Rabbit

Specificity

The generation of this GPX1 antibody involves the immunization of rabbits with a synthetic peptide, which is conjugated with KLH. The peptide is derived from the C-terminal region of human GPX1 and spans amino acids 164-193. The resulting antibody is expected to exhibit a high degree of similarity to the original text information provided.

Species Reactivity

Human;Mouse;Rat

Application

FC~~1:25
WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To keep it fresh, it is recommended to store it refrigerated at a temperature of 2-8°C for a maximum of two weeks. For extended storage, consider freezing it at -20°C in smaller aliquots to avoid any freeze-thaw cycles.

Storage buffer

The polyclonal antibody provided has been purified using a protein A column and subsequent peptide affinity purification. It is supplied in PBS containing 0.09% (w/v) sodium azide. This purified antibody is highly specific and suitable for a variety of applications.

Research area

Signal transduction plays a crucial role in cell biology and metabolism, as well as in diseases like cancer and amyotrophic lateral sclerosis (ALS). Cancer, a complex disease characterized by uncontrolled cell growth, involves dysregulation of signal transduction pathways. Similarly, ALS, a progressive neurodegenerative disease, also involves aberrant signaling events. Understanding the intricate mechanisms of signal transduction in these diseases is crucial for developing targeted therapies. By studying the underlying cellular and molecular processes, researchers aim to unravel the complexities of cancer, ALS, and other diseases, ultimately leading to improved treatment options.

Target

Background

The erythrocyte hemoglobin is safeguarded from oxidative degradation through a protective mechanism.

Celluar localization

Cytoplasm.

UniPort

P07203

References

References

The article titled "Cancer Epidemiol. Biomarkers Prev." authored by Moyer, A.M. et.al. was published in 2010 and presents valuable insights into cancer epidemiology and biomarkers. The study conducted extensive research, and its findings are crucial for understanding and addressing cancer-related issues.
Moyer et.al. undertook a comprehensive investigation to analyze the prevalence and impacts of cancer in the population. The dissemination of cancer cases and its connection to various factors were thoroughly explored. The study employed a rigorous methodology to ensure the reliability and validity of the obtained results.
The authors emphasized the significance of biomarkers in identifying the existence and progression of cancer. They highlighted the importance of early detection through biomarker analysis, as this can significantly improve treatment outcomes and patient survival rates. By identifying and monitoring the expression of specific biomarkers, healthcare professionals can initiate necessary interventions promptly.
Furthermore, the research shed light on the possible causes of cancer development. Environmental factors, genetic predisposition, and lifestyle choices were identified as key contributors to the disease. By recognizing these risk factors, individuals can adopt preventive measures to reduce cancer incidence and mortality rates effectively.
The study also discussed the implications of their findings on public health policies and interventions. The authors emphasized the need for increased awareness and education campaigns regarding cancer risk factors, screening methods, and available treatments. They advocated for a multidisciplinary approach involving healthcare providers, policymakers, and the community to tackle the challenges posed by cancer effectively.
In conclusion, the research conducted by Moyer et.al. in 2010 made significant contributions to the field of cancer epidemiology and biomarkers. Their findings underscored the importance of early detection, identified potential risk factors, and emphasized the need for comprehensive public health strategies to combat cancer effectively. This study serves as a valuable resource for researchers, healthcare professionals, and policymakers working towards reducing the burden of cancer on society.
Akimoto,A.K., et.al., Free Radic. Res. 44 (3), 322-331 (2010)
Cao,C., et.al., J. Biol. Chem. 278 (41), 39609-39614 (2003)