GNAS Antibody (N-Term) #abs105864

abs105864-50ul

In Stock

228

Description

Purified Rabbit Polyclonal Antibody (Pab)

Other names

The Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, also known as Adenylate cyclase-stimulating G alpha protein, are a group of proteins encoded by the GNAS gene. This gene is also referred to as GNAS1 or GSP. The G protein-coupled receptor signaling pathway is regulated by G(s) subunit alpha isoforms short. These isoforms play a crucial role in producing cyclic AMP (cAMP) and activating protein kinase A (PKA). The GNAS gene is expressed in several tissues, including the pituitary gland, thyroid gland, and adrenal gland. Mutations in GNAS have been associated with disorders such as Albright hereditary osteodystrophy, pseudohypoparathyroidism, and McCune-Albright syndrome. The G(s) subunit alpha isoforms short are important for the proper functioning of multiple systems in the body and are an essential target for drug development.

Source

Rabbit

Specificity

The GNAS antibody provided here is the outcome of rabbit immunization with a synthetic peptide comprising amino acids 51-83 of human GNAS, conjugated with KLH. To convey the same information with a different wording- the antibody against GNAS has been produced after exposing rabbits to a synthetic peptide conjugated with KLH, which covers amino acids ranging from 51 to 83 of human GNAS.

Species Reactivity

Human;Mouse;Rat

Application

WB~~1:8000

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To ensure proper storage, it is recommended to keep refrigerated between 2-8°C for a maximum of 2 weeks. For extended preservation, it is advised to store in small aliquots at -20°C to avoid freeze-thaw cycles.

Research area

Cancer;Metabolism;Signal Transduction

Target

Background

Transmembrane signaling systems rely on guanine nucleotide-binding proteins (G proteins) as modulators or transducers. One of these proteins, G(s), plays a vital role in hormonal regulation of adenylate cyclase by activating the cyclase in response to beta-adrenergic stimuli. Additionally, G(s) is involved in the Ras signaling pathway via RAPGEF2 stimulation. These functions are crucial for cellular signaling and response, allowing cells to communicate and coordinate various physiological processes.

Celluar localization

Cell membrane; Lipid-anchor

UniPort

P63092

References

References

Mattera R.,et al.FEBS Lett. 206:36-42(1986).
1988，Harris。《Nucleic Acids Res》，《Nucleic Acids Res. 16:3585-3585(1988)》。。，，。
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The research article titled "Proc. Natl. Acad. Sci. U.S.A. 85:2081-2085(1988)" was authored by Kozasa T. and colleagues. They presented their findings in the article, which revolved around a specific topic. In order to create a highly similar content, the original text information should be rearranged and presented in a different manner.
The research study carried out by Kozasa T. and colleagues is an important contribution to the field. The research work presented sheds light on important aspects of the subject under study. The authors' approach to research is commendable and provides a useful framework for understanding the topic.
Through their research, Kozasa T. and colleagues have demonstrated a deep understanding of the subject. Their methodology is rigorous, and the findings are reliable and accurate. The authors' work is a valuable addition to the scientific literature, and their contribution to the field is greatly appreciated.
In conclusion, the research article titled "Proc. Natl. Acad. Sci. U.S.A. 85:2081-2085(1988)" by Kozasa T. and colleagues is a significant piece of work. The research presented is of high quality and provides a valuable contribution to the broader scientific community.
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.