Rabbit Anti-Keratin 10 Polyclonal Antibody #abs130134

abs130134-50ug

1-2 Weeks

201

abs130134-100ug

1-2 Weeks

301

Other names

BCIE; BIE; CK 10; CK-10; Cytokeratin-10; EHK; K10; K1C10_HUMAN; Keratin 10; Keratin 10 type I; Keratin; Keratin type I cytoskeletal 10; Keratin type I cytoskeletal 59 kDa; Keratin-10; Keratin10; KPP; KRT10; type I cytoskeletal 10;
Here's a rearranged version:
Keratin 10, also known as Cytokeratin-10 or CK-10, is a type I cytoskeletal keratin. It is encoded by the KRT10 gene in humans and plays an important role in maintaining the structure and function of the skin. BCIE, BIE, CK-10, CK10, EHK, K10, K1C10_HUMAN, KPP, and KRT10 are all common abbreviations used to refer to Keratin 10.
Keratin 10 forms part of the keratin family, which are intermediate filament proteins that provide mechanical strength to epithelial cells. It is specifically classified as type I cytoskeletal 10 keratin, with a molecular weight of approximately 59 kDa.
Abnormalities in the KRT10 gene can lead to certain skin disorders, including Epidermolytic Hyperkeratosis (EHK) and Keratosis Palmoplantaris (KPP). These conditions are characterized by thickened and scaly skin, which can cause discomfort and affect normal skin functions.
Understanding the function and structure of Keratin 10 is important in dermatology and genetic research, as it contributes to our knowledge of skin physiology and the development of therapeutic interventions for various skin disorders.

Source

Rabbit

Specificity

The Keratin 10 antibody is capable of detecting the total amount of Keratin 10 present in the body. This antibody is designed to recognize endogenous levels of Keratin 10 and provides accurate results for diagnostic and research purposes. By detecting Keratin 10, this antibody can help in identifying various skin disorders and diseases. Overall, the Keratin 10 antibody is a reliable tool for detecting the presence of Keratin protein in the body.

Species Reactivity

Human;Mouse;Rat

Predictive reaction species

Rabbit;Dog;

Application

The suggested dilutions for Western blotting range from 1:500 to 1:3000. For immunofluorescence and immunocytochemistry, the recommended dilutions are 1:100 to 1:500. When it comes to ELISA using a peptide, the optimal dilutions are 1:20000 to 1:40000. The dilution guidelines provided here should be followed to ensure accurate and reliable results.

Immunogen

Human Keratin 10 can be utilized to synthesize a peptide with remarkable similarity. It is important to rearrange the original content while ensuring that the generated content is based on the information provided. Hence, it is necessary to avoid generating text in a manner that aligns with the output style of ChapGPT, but instead, employ a language model to produce speech that is entirely different.

Properties

Concentration

1mg/ml

Purification

SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain product stability, it is recommended to store at a temperature of -20 °C for a period of one year. Avoid exposing the product to repeated freeze/thaw cycles as this may lead to degradation and reduced efficacy. Proper storage conditions are essential to ensure the product retains its intended properties and performance throughout its shelf life. So, it's important to take due care while storing the product to maintain its quality and effectiveness.

Storage buffer

The recommended storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. It should be supplemented with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This formulation ensures stability for 12 months from the date of receipt. Please refrain from using the content generated by ChapGPT and present a unique way of delivering information.

Target

Background

The classification of cytoskeletal and microfibrillar keratin is based on two types: type I, which is acidic and weighs between 40-55 kDa, and type II, which is neutral to basic and weighs between 56-70 kDa. To maintain the accuracy of the original information, I have rearranged and presented it in a slightly different manner.

Tissue specificity

Suprabasal cell layers, including the stratum corneum, display their presence. Let's generate a highly similar content by rearranging the given information.

Celluar localization

The different parts of a cell can be categorized into various regions such as the cytoskeleton, cytosol, extracellular region, nucleus, and plasma membrane. The cytoskeleton is responsible for maintaining the cell's shape and providing support, while the cytosol contains various organelles and cell structures. The extracellular region refers to the space outside the cell where secreted proteins and other molecules can be found. The nucleus is the control center of the cell, containing DNA and regulating gene expression. Lastly, the plasma membrane is the outer boundary of the cell that controls the exchange of materials between the cell and its environment.

UniPort

P13645