CYP17A1 Polyclonal Antibody #abs115547

abs115547-50ul

In Stock

228

Other names

CPT7;CYP17;P450C17;S17AH

Source

Rabbit

Species Reactivity

Human,Mouse,Rat

Application

WB 1:500 - 1:2000
IF 1:50 - 1:200

Immunogen

Human CYP17A1 (NP_000093.1), specifically amino acids 209-508, forms the basis of a recombinant fusion protein. The reorganized content should maintain the original information but in a significantly different manner.

Properties

MCF7,Jurkat,Mouse liver,Mouse testis

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
The pH of the buffer is 7.3, and it consists of 0.02% sodium azide and 50% glycerol. Additionally, the buffer contains PBS and is preserved with sodium azide for stability. To enhance viscosity and improve sample handling, glycerol is added at a concentration of 50%.

Target

Background

This particular gene belongs to the cytochrome P450 superfamily of enzymes. These proteins play a key role in many biological processes, such as drug metabolism, cholesterol synthesis, and lipid synthesis. This gene is located in the endoplasmic reticulum and is responsible for both 17alpha-hydroxylase and 17,20-lyase activities. It is a critical enzyme in the steroidogenic pathway, which produces a variety of hormones, including progestins, glucocorticoids, mineralocorticoids, androgens, and estrogens.
Mutations in this gene can result in a range of conditions, including isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. These conditions can have significant impacts on an individual's health and wellbeing, highlighting the crucial role that this gene plays in maintaining hormonal balance in the body. Further research into the functions and regulation of this gene may offer new insights into the development of treatments for these conditions.

Celluar localization

Membrane

UniPort

P05093