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CBS Polyclonal Antibody #abs115559

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Description

Catalog-specification	Delivery time	USD price
abs115559-50ul	In Stock	228

Overview
Other names	HIP4
Source	Rabbit
Species Reactivity	Human,Mouse,Rat
Application	WB 1:500 - 1:2000 IF 1:50 - 1:200
Immunogen	A fusion protein made by combining different sequences in order to create a new protein contains a segment that is identical to amino acids 252-551 of human CBS (NP_000062.1). Can you produce another text that expresses the same information, but in a different structure, based on the original text?
Properties	HeLa,MCF-7,THP-1,Ramos,Mouse kidney,Mouse brain
Properties
Purification	Affinity purification
Clonality	Polyclonal Antibody
Isotype	IgG
Stability & Storage	Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. The pH of the buffer is 7.3 and it contains 0.02% sodium azide. Additionally, it has 50% glycerol.
Target
Background	This gene encodes a protein that functions as a homotetramer in catalyzing the conversion of homocysteine to cystathionine, which marks the initial step of the transsulfuration pathway. This protein is activated by adenosyl-methionine through allosteric regulation and relies on pyridoxal phosphate as a cofactor. Disruptions in this gene can lead to cystathionine beta-synthase deficiency (CBSD) characterized by homocystinuria. Furthermore, this gene plays a crucial role in the production of hydrogen sulfide within cells. Notably, multiple transcript variants of this gene have been identified through alternative splicing.
Celluar localization	Cytoplasm,Nucleus
UniPort	P35520

Data Examples

Western blot analysis of extracts of various cell lines, using CBS antibody (abs115559) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.