Bak Antibody (BH3 Domain Specific) #abs101724

abs101724-50ul

In Stock

228

Description

Purified Rabbit Polyclonal Antibody (Pab)

Other names

BAK1, also known as Bcl-2 homologous antagonist/killer or Apoptosis regulator BAK, is a protein involved in apoptosis regulation. It is also referred to as Bcl-2-like protein 7, Bcl2-L-7, and CDN1. BAK1 plays a crucial role in controlling cell death by promoting apoptosis. Its presence in cells helps initiate the cell death process when necessary. BAK1 has been extensively studied due to its importance in maintaining cell balance and preventing the formation of cancerous cells. Understanding the function and regulation of BAK1 can provide valuable insights into developing new therapies for various diseases, particularly those associated with uncontrolled cell growth. Further research on BAK1 could potentially lead to the development of targeted treatments aimed at restoring normal cellular processes and preventing disease progression.

Source

Rabbit

Specificity

The Bak antibody is derived from rabbits that have been immunized with a synthetic peptide consisting of amino acids 56 to 91 from the human Bak protein. This peptide is conjugated with KLH. To create a similar content, you can rearrange the information as follows:
Rabbits were immunized with a synthetic peptide, which is conjugated with KLH, containing amino acids 56 to 91 from the human Bak protein. The generated Bak antibody is highly specific and recognizes Bak protein with high affinity.

Species Reactivity

Human

Application

WB~~1:2000
IHC-P~~1:50~100

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To maintain the quality of the product, it is recommended to store it in a refrigerated environment with a temperature ranging from 2-8°C for up to 2 weeks. For longer storage periods, freezing at -20°C is ideal, but make sure to store the product in small aliquots to avoid any freeze-thaw cycles. This will ensure the integrity of the product and maintain its efficacy when used. Follow these guidelines, and you can enjoy the benefits of the product for an extended period.

Storage buffer

The purified polyclonal antibody is provided in PBS and contains 0.09% (W/V) sodium azide. The antibody is carefully purified through a protein G column, using high and low pH buffers to elute it. The eluted antibody is promptly neutralized and then dialyzed against PBS. This ensures that the antibody is of high quality and purity, and is ready for use in laboratory experiments or clinical applications.

Research area

Cell Biology

Target

Background

BCL2 or its adenovirus homolog E1B 19k protein can be antagonized and inhibited by an appropriate stimulus, leading to the acceleration of programmed cell death. The apoptotic action can be enhanced by the presence of low micromolar levels of zinc ions.

Celluar localization

A membrane called the mitochondrion membrane houses a protein known as a single-pass membrane protein. To create new content that closely follows this original information, one could try phrasing it like this: "At the heart of every mitochondrion is a specialized membrane that plays host to a single-pass membrane protein. This protein is crucial for the proper functioning of the organelle."

UniPort

Q16611

References

References

Cartron, P.F., et al., Mol. Cell. Biol. 23(13):4701-4712 (2003).
Mikhailov, V., et al., J. Biol. Chem. 278(7):5367-5376 (2003).
Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).
Bellosillo, B., et al., Blood 100(5):1810-1816 (2002).
Grutkoski, P.S., et al., Shock 17(1):47-54 (2002).