Phospho-Catenin-beta (Ser37) Rabbit Polyclonal Antibody#abs130893

abs130893-50ug

1-2 Weeks

201

abs130893-100ug

1-2 Weeks

301

Description

The protein beta-catenin is a crucial component of adherens junctions, which are responsible for creating and maintaining epithelial layers in various organs. These junctions serve multiple functions, including mediating cell adhesion, signaling the presence of neighboring cells, and anchoring the actin cytoskeleton. Through these roles, adherens junctions play a vital role in regulating normal cellular growth and behavior.

Other names

Beta catenin, also known as catenin (cadherin associated protein), beta 1, 88kDa, is a cadherin associated protein that plays an important role in cell adhesion and cell signaling pathways. It is encoded by the CTNNB1 gene and is involved in the Wnt signaling pathway, which is important for embryonic development and tissue homeostasis. Beta-catenin is a key player in regulating cell proliferation, differentiation, and polarity, as well as in tissue regeneration and repair. It is also involved in the development and maintenance of various organs, including the brain, liver, and heart. Additionally, beta-catenin has been implicated in several diseases, such as cancer, Alzheimer's disease, and osteoporosis. Understanding the functions and mechanisms of beta-catenin is critical for the development of effective therapies to treat these diseases.

Source

Rabbit

Specificity

This antibody known as Phospho-Catenin-β (Ser37) Antibody is capable of detecting natural levels of Catenin-β when it has been phosphorylated at the Serine 37 site. It is important to note that this antibody will not detect non-phosphorylated Catenin-β.

Predictive reaction species

Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig

Application

IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500, and ELISA (peptide) 1:20000-1:40000 are the recommended dilution ranges for different techniques.

Catenin-β37。，。

Properties

1mg/ml

Purification

，。，。

Clonality

Polyclonal Antibody

To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freezing and thawing cycles to maintain its quality and effectiveness.

Storage buffer

The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in a solution containing phosphate buffered saline at pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the IgG is guaranteed for 12 months from the date of receipt.

Target

Background

 Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

Tissue specificity

Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level).

Celluar localization

Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;

P35222