Rabbit Anti-CaMK2-beta/gamma/delta Polyclonal Antibody#abs131926
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Description
| Catalog-specification | Delivery time | USD price |
abs131926-100ug | 1-2 Weeks | 301.0 |
abs131926-50ug | 1-2 Weeks | 201.0 |
Please be advised that the price mentioned above is provided for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. It is important to note that the generated content will be significantly different from the original text information as it will be created using a language model, rather than following the dialogue generation approach of ChapGPT.
| Overview | |
catalog | abs131926 |
Description | This particular gene is a member of the serine/threonine protein kinase family, and falls under the Ca(2+)/calmodulin-dependent protein kinase subfamily. The role of calcium signaling in the modulation of plasticity in glutamatergic synapses cannot be overstated. |
| Other names | Calcium/calmodulin-dependent protein kinase type II (CaMKII) is an important enzyme that plays a key role in regulating various cellular processes in the brain and other tissues. Two subtypes of CaMKII, alpha and delta, have been identified and extensively studied. CaMKII alpha is highly concentrated in the brain and is essential for synaptic plasticity and long-term potentiation (LTP), which are critical for learning and memory. CaMKII delta, on the other hand, is widely expressed throughout the body and is involved in a variety of cellular functions, including cell cycle regulation, gene transcription, and ion channel modulation. The CaMKII enzyme functions as a holoenzyme composed of several subunits, with the alpha and delta subunits being the most well-characterized. The alpha subunit is encoded by the CAMK2A gene, while the delta subunit is encoded by the CAMK2D gene. Both genes are highly conserved across species, indicating their importance in maintaining cellular homeostasis. In addition to its structural importance, CaMKII is also regulated by its activation and inactivation states. Upon binding to calcium and calmodulin, CaMKII undergoes autophosphorylation, which in turn leads to its sustained activation even after the initial calcium and calmodulin signals have dissipated. This characteristic allows CaMKII to function as a memory molecule, enabling the long-term storage of information in synapses. Overall, the CaMKII enzyme is a critical player in cellular signaling and regulation, with its alpha and delta subtypes playing distinct yet complementary roles. Further research into these subtypes and their functions may lead to the development of novel therapies for various neurological and psychiatric disorders. |
| Source | Rabbit |
| Specificity | The CaMK2-beta/gamma/delta Antibody is capable of detecting the total levels of endogenous CaMK2-beta/gamma/delta proteins. To clarify, this antibody can accurately identify and quantify the presence of all three isoforms of CaMK2, namely beta, gamma, and delta. Its specificity enables it to distinguish between these isoforms and other CaMK2 variants. Consequently, this antibody is highly reliable for studying the distribution and expression levels of CaMK2-beta/gamma/delta in various biological samples. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Xenopus;Rabbit;Pig;Sheep;Horse;Bovine; |
| Antigen | CaMK2-β/gamma/delta |
| Application | The recommended dilutions for Western Blot (WB) range from 1:500 to 1:2000. For Immunohistochemistry (IHC), the suggested dilutions are between 1:50 and 1:200. As for ELISA using peptide as the target, dilutions of 1:20000 to 1:40000 are recommended. It is important to adhere to these dilutions to achieve accurate results in your experiments. |
| Immunogen | We can create a peptide by combining certain sequences from human CaMK2-beta, gamma, and delta. This synthesized peptide will be highly similar to the original sequences, ensuring that it retains the same information as the original text. The peptide can be used for research and therapeutic purposes. By rearranging the amino acid sequences of these proteins, we can generate a new molecule that retains their essential properties and functions. This is a powerful tool in molecular biology that enables scientists to study the structure and function of proteins in greater detail. |
| MW | 50+65kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. |
| Tissue specificity | Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. |
| Posttranslational modification | Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
| Celluar localization | Cytoskeleton;Cytosol;Endoplasmic reticulum;Nucleus;Plasma Membrane; |
| UniPort | Q13554/Q13555/Q13557 |
Western blot analysis of CaMK2-beta/gamma/delta expression in Rat braintissue lysates,The lane on the left is treated with the antigen-specific peptide.
This product is for research use only, not for use in diagnostic prodecures or in human.
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