Rabbit Anti-Cathepsin D Polyclonal Antibody#abs131281
Please note that the provided price is only for your reference. For specific pricing details, kindly get in touch with our seller, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.
Description
| Catalog-specification | Delivery time | USD price |
abs131281-100ug | 1-2 Weeks | 301.0 |
abs131281-50ug | 1-2 Weeks | 201.0 |
Please note that the provided price is only for your reference. For specific pricing details, kindly get in touch with our seller, Vecent.
| Overview | |
catalog | abs131281 |
Description | The acid protease is a crucial enzyme for intracellular protein degradation. It plays a significant role in the development of various ailments, including breast cancer and potentially Alzheimer's disease. |
| Other names | Cathepsin D, also known as CD or CatD_HUMAN, is a lysosomal aspartyl protease that plays a role in various biological processes. It consists of a heavy chain and is associated with ceroid lipofuscinosis neuronal 10 (CLN10). This protein is also referred to as CPSD or ctsd. Additionally, it is involved in the binding of sperm in the epididymis and is known as epididymis secretory sperm binding protein Li 130P or HEL S 130P. In the context of the human genome, this encoded protein is designated as MGC2311. |
| Source | Rabbit |
| Specificity | The presence of total Cathepsin D can be detected using the Cathepsin D Antibody, which is capable of identifying endogenous levels of this protein. To clarify, the antibody specifically recognizes and binds to Cathepsin D, enabling the detection and measurement of its total amount in a sample. |
| Species Reactivity | Human |
| Antigen | Cathepsin D |
| Application | The recommended dilution ratios for WB are 1:500-1:2000, for IHC are 1:50-1:200, for IF/ICC are 1:100-1:500, and for ELISA (peptide) are 1:20000-1:40000. It is important to note that these dilution ratios are based on the original text information provided. |
| Immunogen | A synthetic peptide derived from human Cathepsin D is available. The following content is a close rephrasing of the original text, while maintaining the information provided. |
| MW | 44 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished via peptide affinity chromatography. A highly similar content can be generated by rearranging the sentence structure while retaining the same information as the original text. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure the longevity of your product, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this can affect its quality and efficacy. By following these guidelines, you can be assured that your product will remain in optimal condition for an extended period of time. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
| Tissue specificity | Expressed in the aorta extrcellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530). |
| Posttranslational modification | N- and O-glycosylated.Undergoes proteolytic cleavage and activation by ADAM30.As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified (PubMed:1426530). An additional form starting at Ala-168 has also been identified (PubMed:27333034). |
| Celluar localization | Extracellular region or secreted;Lysosome; |
| UniPort | P07339 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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