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Rabbit Anti-ACVL1 Polyclonal Antibody#abs133472

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Description

Catalog-specification	Delivery time	USD price
abs133472-100ug	1-2 Weeks	301.0
abs133472-50ug	1-2 Weeks	201.0

Overview
catalog	abs133472
Other names	The Activin A receptor, also known as Activin A receptor type II like 1, Activin A receptor type II like kinase 1, Activin receptor like kinase 1, or Activin receptor-like kinase 1, is a serine/threonine protein kinase receptor R3. It is also referred to as SKR3, TSR-I, or TSR1. This protein is a TGF B superfamily receptor type I, which plays a role in regulating various physiological functions in the body. ALk-1 is the other name for this receptor, and it is associated with HHT (Hereditary hemorrhagic telangiectasia) or Osler-Weber-Rendu syndrome. The condition is characterized by abnormal blood vessel growth, which can lead to bleeding in various parts of the body. This receptor is essential for the correct formation of blood vessels and is important for the maintenance of vascular integrity. Activin A receptor plays a crucial role in angiogenesis, the process by which new blood vessels are formed from pre-existing vessels. It also plays a role in inflammation and wound healing. Disruptions to this pathway have been associated with numerous diseases, including cancer and cardiovascular diseases. In conclusion, Activin A receptor is a vital component of the TGF B superfamily receptor type I, playing a role in various physiological functions. Its important role in angiogenesis and maintaining vascular integrity makes it a key target for research into numerous diseases.
Source	Rabbit
Specificity	The endogenous levels of total ACVL1 can be accurately detected using the ACVL1 antibody. The antibody is specifically designed to recognize ACVL1 and has the ability to detect its natural levels within the organism. This ensures reliable and precise measurement of ACVL1 protein expression. By utilizing the ACVL1 antibody, researchers can gather valuable information about the role and function of ACVL1 in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	ACVL1
Application	The recommended dilutions for using the antibody in various applications are as follows: for Western blotting, dilute the antibody at 1:500 to 1:1000; for immunohistochemistry, dilute it at 1:50 to 1:200; for immunofluorescence or immunocytochemistry, dilute it at 1:100 to 1:500; and for ELISA with peptide substrates, dilute it at 1:20000 to 1:40000. These dilutions are well-suited for detecting the target protein with high sensitivity and specificity.
Immunogen	A synthesized peptide.
MW	56 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography. This process allowed us to produce a highly purified and concentrated antiserum that was free from contaminants.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Celluar localization	Plasma Membrane;
UniPort	P37023