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Rabbit Anti-BNIP3L Polyclonal Antibody#abs137640

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Description

Catalog-specification	Delivery time	USD price
abs137640-100ug	1-2 Weeks	301.0
abs137640-50ug	1-2 Weeks	201.0

Overview
catalog	abs137640
Other names	The protein known as Adenovirus E1B19k binding protein B5, also referred to as Adenovirus E1B19K-binding protein B5, is involved in various cellular processes. It interacts with the BCL2/adenovirus E1B 19 kd protein, functioning as a key interacting partner. This interaction is mediated through the BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, also known as BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like or BNIP3a. Additionally, the protein can be labeled as BCL2/adenovirus E1B 19kDa interacting protein 3 like or BNIP3L, BNIP3H, or BNIP3L protein. It is worth mentioning that this protein is also referred to as NIP3-like protein X or NIX. It plays a significant role in various cellular activities.
Source	Rabbit
Specificity	The BNIP3L Antibody is capable of detecting total BNIP3L at its natural levels within the body.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Rabbit;Pig;Sheep;Horse;Bovine;Chicken
Antigen	BNIP3L
Application	What are the dilution ratios for Western blot (WB), immunofluorescence (IF)/immunocytochemistry (ICC), and ELISA (peptide)? For WB, the dilution ratio ranges from 1:1000 to 1:3000. For IF/ICC, the dilution ratio ranges from 1:100 to 1:500. And for ELISA (peptide), the dilution ratio ranges from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human BNIP3L.
MW	35 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. The purification process resulted in high purity levels of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the items, it is recommended to store them at -20 °C for a duration of one year. It is important to avoid subjecting them to repeated cycles of freezing and thawing. Properly following these guidelines will help maintain their quality and integrity over time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Posttranslational modification	Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
Celluar localization	Cytosol;Endoplasmic reticulum;Mitochondrion;Nucleus;
UniPort	O60238