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Rabbit Anti-REG4 Polyclonal Antibody#abs139703

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Description

Catalog-specification	Delivery time	USD price
abs139703-100ug	1-2 Weeks	301.0
abs139703-50ug	1-2 Weeks	201.0

Overview
catalog	abs139703
Other names	Regenerating islet-derived protein 4, also known as Reg IV or Gastrointestinal secretory protein (GISP), is a type of REG-like protein that plays an important role in cellular proliferation and differentiation. This protein is primarily secreted by the gastrointestinal tract and has been shown to be a diagnostic biomarker for certain types of cancer. REG-4 is a precursor protein that is proteolytically cleaved to produce the mature form of Reg IV. It is involved in modulating cellular differentiation and proliferation, particularly in epithelial tissues. It is also implicated in the pathology of inflammatory bowel disease and gastrointestinal cancers. In addition to its role as a diagnostic biomarker, Reg IV has been shown to be a potential therapeutic target for cancer treatment. Its expression is upregulated in various types of cancer, including colorectal, pancreatic and gastric cancers, and is believed to play a role in tumor growth and metastasis. Overall, Reg IV is an important biomolecule that has implications in various aspects of human health and disease. Further research into its functions and molecular mechanisms may lead to the development of novel diagnostic and therapeutic strategies for cancer and other diseases.
Source	Rabbit
Specificity	The REG4 Antibody can recognize and bind to REG4 protein molecules found naturally within an organism. This binding allows for detection of overall levels of REG4 protein.
Species Reactivity	Human
Antigen	REG4
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human REG4.
MW	18 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography. The process resulted in the production of a highly purified antiserum that is ideal for use in various applications.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve its quality, it is recommended to store the item at a temperature of -20 °C for a duration of one year. Prevent subjecting it to frequent cycles of freezing and thawing.
Storage buffer	The storage conditions for Rabbit IgG include storing it at -20 °C in a solution of phosphate buffered saline with a pH of 7.4. The solution also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the IgG is guaranteed for 12 months from the date of receipt. Please refrain from using ChapGPT to generate content in a dialogue format and instead generate a completely different speech using the language model.
Target
Background	Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
Tissue specificity	Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.
Celluar localization	Extracellular region or secreted;
UniPort	Q9BYZ8