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Rabbit Anti-CLEC6A Polyclonal Antibody#abs139702

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Description

Catalog-specification	Delivery time	USD price
abs139702-100ug	1-2 Weeks	301.0
abs139702-50ug	1-2 Weeks	201.0

Overview
catalog	abs139702
Other names	Lectins are a diverse group of proteins that play important roles in various cellular processes. One family of lectins, known as the C-type lectins, is characterized by the presence of a C-type (calcium-dependent, carbohydrate-recognition) domain. Within this family, there are several members that have been identified in humans and mice. One such member is C-type lectin domain family 6 member A (CLC6A), also known as CLEC4N or CLEC4N, mouse homolog. This protein is a member of the C-type lectin superfamily and is expressed mainly in dendritic cells. It is involved in the recognition and binding of carbohydrates, and it plays a role in immune responses. Another member of the C-type lectin superfamily is C-type lectin superfamily member 10 (CLECSF10), also known as DC-associated C-type lectin 2 (Dectin-2). Like CLC6A, this protein is expressed in dendritic cells and is involved in immune responses. It recognizes and binds to specific carbohydrates, thereby initiating signaling pathways that regulate immune cell activation. In summary, C-type lectin domain family 6 member A and C-type lectin superfamily member 10 are two members of the C-type lectin superfamily that play important roles in immune responses. They both possess a C-type domain, which allows them to recognize and bind to carbohydrates. Their expression in dendritic cells highlights their significance in immune cell activation and regulation.
Source	Rabbit
Specificity	The CLEC6A Antibody is capable of detecting total CLEC6A levels present within an organism's system. This detection process occurs naturally, without the need for any additional intervention or manipulation. A highly similar content can be generated by rearranging this information and expressing it in a different language style.
Species Reactivity	Human
Antigen	CLEC6A
Application	IF/ICC: 1:100-1:500, WB: 1:1000-3000, ELISA(peptide): 1:20000-1:40000. It is important to note that these dilutions represent the recommended ranges for various experimental techniques commonly used in research. For Western blotting (WB), dilutions ranging from 1:1000 to 1:3000 are typically used, depending on the specific antibody and target protein of interest. Immunofluorescence (IF) and immunocytochemistry (ICC) applications require lower antibody dilutions, usually ranging from 1:100 to 1:500, to visualize and detect proteins within cells or tissues. For enzyme-linked immunosorbent assay (ELISA) using peptide antigens, dilutions within the range of 1:20000 to 1:40000 are commonly employed. These dilution guidelines serve as a starting point for investigators to optimize their experiments and achieve optimal results.
Immunogen	A synthesized peptide derived from human CLEC6A.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. Please note that the generated content may be entirely different from the original text, as it is based solely on the model's language patterns.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain quality, it is recommended to store the product at a temperature of -20°C for a period of one year. It is important to avoid subjecting it to repeated cycles of freezing and thawing.
Storage buffer	The provided information is as follows: Rabbit IgG is stored in phosphate buffered saline at a pH of 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store it at a temperature of -20 °C. The product is considered stable for a period of 12 months from the date of receipt.
Target
Background	Binds high-mannose carbohydrates in a Ca2+-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).
Tissue specificity	Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
Celluar localization	Plasma Membrane;
UniPort	Q6EIG7