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Rabbit Anti-SLC9A3 Polyclonal Antibody#abs139457

Please note that the price provided is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis SLC9A3 using COLO205 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs139457-100ug	1-2 Weeks	301.0
abs139457-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs139457
Other names	Na(+)/H(+) exchanger 3, also known as NHE3 or NHE-3, belongs to the solute carrier family 9 (SLC9A3) and is a crucial protein involved in sodium and hydrogen ion exchange within cells. It plays a vital role in maintaining the acid-base balance and regulating fluid volume in various tissues, particularly in the renal tubules. The gene encoding NHE3 is referred to as MGC126718 or MGC126720, and its human protein sequence is denoted as SL9A3_HUMAN or Solute carrier family 9 member 3. NHE3 is predominantly expressed in the apical epithelial cells of organs like the kidneys, intestines, and lungs. NHE3 acts as a transmembrane transporter, using the energy released from the downhill movement of sodium to drive the uphill transport of hydrogen ions across the cell membrane. This process helps to maintain cellular pH and regulate ion concentrations. Moreover, NHE3 also aids in the reabsorption of sodium and bicarbonate ions in the kidney tubules, contributing to the maintenance of electrolyte and water balance. Disruptions or malfunctions in NHE3 activity can lead to various disorders. For instance, alterations in NHE3 expression or function have been implicated in conditions like hypertension, renal tubular acidosis, and inflammatory bowel disease. In summary, NHE3, encoded by the SLC9A3 gene, is a crucial sodium/hydrogen exchanger protein that facilitates the exchange of ions across cell membranes. Its expression and activity are vital for maintaining electrolyte balance, pH regulation, and fluid homeostasis in multiple organs.
Source	Rabbit
Specificity	Endogenous levels of total SLC9A3 can be detected using the SLC9A3 antibody. The antibody is designed to specifically recognize SLC9A3 and can be used in various applications to detect its expression. It is important to use a highly specific antibody to ensure accurate detection of the protein of interest. The SLC9A3 antibody can be a valuable tool for researchers studying the function and regulation of SLC9A3 in various biological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	SLC9A3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SLC9A3.
MW	93kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we have successfully purified the antiserum through peptide affinity chromatography. The resulting product is of high quality and similarity to the original antibody.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, it is recommended to place the product in a freezer at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing as this may compromise the product's quality and efficacy. Take note of these instructions to ensure that the product stays in its best condition.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide, along with 50% glycerol. It should be stored at -20 °C and has a shelf life of 12 months from the date of receipt. Please ensure that you follow the storage instructions to maintain its quality.
Target
Background	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
Posttranslational modification	Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P48764