Rabbit Anti-FGFR1 Oncogene Partner Polyclonal Antibody #abs130095

abs130095-50ug

1-2 Weeks

201

abs130095-100ug

1-2 Weeks

301

Description

The centrosomes rely on FOP to securely anchor microtubules. FOP acts as a homodimer and forms a crucial part of a ternary complex alongside CEP350, FGFR1OP, and MAPRE1. It directly interacts with both CEP350 and MAPRE1. In humans, alternative splicing leads to the production of three isoforms of this protein.

Other names

The FGFR1 oncogene partner, also known as FGFR1OP or FOP, is a protein that forms a complex with the fibroblast growth factor receptor 1 (FGFR1) oncogene. This complex is involved in various signaling pathways that play crucial roles in normal cellular processes such as cell proliferation and differentiation. The FR1OP_HUMAN gene encodes this protein, and there are two known transcript variants of this gene that arise through alternative splicing. Additionally, the human genome encodes two uncharacterized FGFR1OP pseudogenes. Given its important role in cellular processes, dysregulation of FGFR1OP signaling has been implicated in various diseases, including cancer and developmental disorders.

Source

Rabbit

Specificity

The endogenous levels of total FGFR1 Oncogene Partner can be detected by using the FGFR1 Oncogene Partner antibody. This antibody specifically targets and recognizes the FGFR1 Oncogene Partner protein in biological samples. By detecting the presence of total FGFR1 Oncogene Partner, researchers can gain insights into its expression levels and potentially study its role in various cellular processes and diseases.

Species Reactivity

Human;Mouse;Rat

Predictive reaction species

Pig;Bovine;Dog;Horse;

Application

For Western blotting, the recommended dilutions range from 1:500 to 1:3000. Immunohistochemistry should be performed using dilutions of 1:50 to 1:200. If you are conducting immunofluorescence or immunocytochemistry, the appropriate dilutions would be 1:100 to 1:500. For ELISA using a peptide substrate, dilutions of 1:20000 to 1:40000 are suggested.

Immunogen

A peptide that has been synthesized from the human FGFR1 Oncogene Partner is available. If you require a highly similar content to the original text, it can be created by rearranging the information given. With this approach, the generated content will be based on the original text and provide accurate information. Please note that this process does not involve using ChapGPT to generate content. Instead, it uses a language model to produce text that is different from the original content.

Properties

Concentration

1mg/ml

Purification

We used SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. Please ensure that the content generated is based on the original text information but rearranged in a different manner.

Clonality

Polyclonal Antibody

Stability & Storage

The recommended storage condition for one year is at -20 °C. It is important to avoid subjecting the product to repeated freeze/thaw cycles.

Storage buffer

This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at -20°C and it should remain stable for up to 12 months from the date of receipt.

Target

Background

To maintain the stability of microtubules, it is essential to anchor them to the centrosomes, which is facilitated by a protein. Additionally, this protein is crucial for promoting ciliation, a process that facilitates cell mobility. Recent studies have highlighted the indispensable role of this protein in these cellular processes, emphasizing its significance in maintaining overall cellular function and homeostasis.

Tissue specificity

This gene is ubiquitous in its expression, with high levels found in various organs and tissues such as the heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.

Celluar localization

Cytoskeleton;Cytosol;Nucleus;

UniPort

O95684