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Rabbit Anti-MUC5B Polyclonal Antibody#abs139160

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Description

Catalog-specification	Delivery time	USD price
abs139160-100ug	1-2 Weeks	301.0
abs139160-50ug	1-2 Weeks	201.0

Overview
catalog	abs139160
Other names	MUC5B, also known as cervical mucin, is a high molecular weight salivary mucin MG1 that is expressed in various tissues including the sublingual gland and tracheobronchial region. It is an oligomeric mucus/gel forming mucin that plays a crucial role in mucosal defense and lubrication. The gene is often referred to by different names such as A130042M24, AV085033, or MUC9. MUC5B is a subtype of the mucin 5 family, and its protein structure contributes to the structure and function of the mucous layer. Understanding the role that MUC5B plays in the body can provide insight into potential therapeutic targets for various respiratory diseases.
Source	Rabbit
Specificity	Endogenous levels of total MUC5B can be detected using the MUC5B Antibody.
Species Reactivity	Human
Antigen	MUC5B
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MUC5B.
MW	596kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to keep the product stored at a temperature of -20°C for a period of one year. To prevent any damage or deterioration, it is important to avoid exposing the product to repeated freeze/thaw cycles.
Storage buffer	The Rabbit IgG is preserved in a solution containing phosphate buffered saline at a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, it should be stored at a temperature of -20 °C. This product has a shelf life of 12 months starting from the date of receipt.
Target
Background	Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
Tissue specificity	Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.
Posttranslational modification	Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	Q9HC84