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Rabbit Anti-MUC5A Polyclonal Antibody#abs139159

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Description

Catalog-specification	Delivery time	USD price
abs139159-100ug	1-2 Weeks	301.0
abs139159-50ug	1-2 Weeks	201.0

Overview
catalog	abs139159
Other names	Apomucin, also known as the Major Airway Glycoprotein or Gastric mucin, is a glycoprotein that plays an important role in the respiratory and digestive systems. It is also referred to as the LeB or Lewis B blood group antigen and is a major component of the mucus layer that coats and protects these systems. Mucin 5 is a subtype of Apomucin that is found in the tracheobronchial and gastric systems. It is further divided into subtypes A and C based on its structural composition. It is also known as Tracheobronchial Mucin (TBM) as it is predominantly found in the airways. Mucin 5AC is a specific subtype of Apomucin that forms oligomeric mucus and gel. It is an important factor in maintaining the integrity of the mucus layer and providing protection against pathogens and environmental insults. Overall, Apomucin and its various subtypes play a crucial role in protecting the respiratory and digestive systems and maintaining their proper functioning.
Source	Rabbit
Specificity	The MUC5A Antibody has the ability to detect the overall levels of endogenous MUC5A in a given sample. This means that it can accurately identify and measure the presence of MUC5A in biological samples, providing valuable insights into its functions and roles in various physiological processes. The antibody's specificity and sensitivity make it an essential tool for researchers studying MUC5A and its potential therapeutic applications. So, the MUC5A Antibody holds immense importance in the field of biomedical research.
Species Reactivity	Human
Antigen	MUC5A
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MUC5A.
MW	586kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimum storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid any repeated freeze/thaw cycles during this time. This will help to maintain the product's quality and efficacy, and ensure that it can be used safely and effectively when required. So, it is advisable to handle and store the product carefully, according to the recommended guidelines.
Storage buffer	The Rabbit IgG is stored in phosphate buffered saline at a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to keep it stored at -20 °C for optimal preservation. The stability of the product is guaranteed for 12 months starting from the date of receipt.
Target
Background	Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
Tissue specificity	Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.
Posttranslational modification	C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	P98088