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Rabbit Anti-APOL1 Polyclonal Antibody#abs140864

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Description

Catalog-specification	Delivery time	USD price
abs140864-100ug	1-2 Weeks	301.0
abs140864-50ug	1-2 Weeks	201.0

Overview
catalog	abs140864
Other names	APOL L; Apo-L; ApoL; APOL I; ApoL-I; APOL1; APOL1_HUMAN; APOLI; Apolipoprotein L; Apolipoprotein L I; Apolipoprotein L-I; Apolipoprotein L1; FSGS4; these are all various names and abbreviations used to refer to the same protein known as apolipoprotein L1. Apolipoprotein L1, or ApoL1, is a protein that is primarily found in the human bloodstream. Research has shown that variations in the APOL1 gene, which encodes the ApoL1 protein, can increase the risk of developing certain kidney diseases, such as focal segmental glomerulosclerosis (FSGS). FSGS is a condition that affects the filtering units of the kidneys, causing scarring and loss of kidney function. ApoL1 is part of a family of proteins called apolipoproteins, which are involved in the metabolism and transport of lipids, such as cholesterol and triglycerides, in the body. These proteins play a crucial role in maintaining the balance of lipids in the bloodstream. The exact function of ApoL1 is not fully understood, but it is believed to have a role in protecting against certain microbial infections. ApoL1 has been shown to be toxic to trypanosomes, which are parasites that cause African sleeping sickness. This indicates that ApoL1 may play a role in the body's defense against certain pathogens. Variations in the APOL1 gene have also been associated with an increased risk of developing other kidney diseases, such as hypertension-attributed end-stage kidney disease (H-ESKD). These variations are more prevalent in individuals of African ancestry, which may explain the higher incidence of kidney disease in this population. Further research is needed to fully understand the role of ApoL1 and its variations in kidney disease. However, studying this protein and its genetic variations could provide valuable insights into the mechanisms underlying these diseases and potentially lead to the development of targeted therapies. In conclusion, ApoL1 is an important protein involved in lipid metabolism and may also play a role in the body's defense against certain infections. Variations in the APOL1 gene have been associated with an increased risk of developing kidney diseases, particularly in individuals of African ancestry. Further research is needed to fully understand the function of ApoL1 and its implications for disease prevention and treatment.
Source	Rabbit
Specificity	Total APOL1 can be detected using APOL1 Antibody, which specifically targets the endogenous levels of the protein.
Species Reactivity	Human
Antigen	APOL1
Application	IF/ICCELISA(peptide)，1:500~1:10001:100-1:500。WB，1:20000-1:40000。，，。。WB，1:500~1:1000。IF/ICC，1:100-1:500。ELISA(peptide)，1:20000-1:40000。
Immunogen	A synthesized peptide.
MW	44 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography. This ensured that the final product was highly purified and of excellent quality.
Clonality	Polyclonal Antibody
Stability & Storage	It is advised to keep the product at a temperature of -20°C for up to a year. To maintain the quality and effectiveness of the product, it is important to avoid repeated cycles of freezing and thawing. Ensuring proper storage conditions can help to prolong the shelf life of the product.
Storage buffer	Phosphate buffered saline, pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol is the ideal storage solution for Rabbit IgG. It is recommended to store this solution at -20 °C for optimal stability. This product can be stored for up to 12 months from the date of receipt.
Target
Background	Lipid exchange and transport are key functions that this entity is involved in throughout the body. Its role in reverse cholesterol transport, where it helps in moving cholesterol from peripheral cells to the liver, is particularly significant.
Tissue specificity	Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Posttranslational modification	Phosphorylated by FAM20C in the extracellular medium.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	O14791