Rabbit Anti-FOXP2 Polyclonal Antibody#abs131137

abs131137-50ug

1-2 Weeks

201

abs131137-100ug

1-2 Weeks

301

Description

This transcriptional repressor has been implicated in the regulation of lung epithelium specification and differentiation. Furthermore, it is believed to have a significant role in the development of neural, gastrointestinal, and cardiovascular tissues. While it can cooperate with CTBP1 to repress transcription synergistically, CTBP1 is not indispensible for its function. Notably, this repressor is involved in the neural mechanisms that underlie the intricate development of speech and language.

Other names

FOX P2, also known as Forkhead box protein P2 or FOXP2, is a forkhead/winged-helix transcription factor that plays a critical role in speech and language development. This protein is encoded by the Trinucleotide repeat containing gene 10 (TNRC10) and is characterized by a CAG repeat in its structure, which can lead to developmental speech and language disorders when mutated. CAGH44 and DKFZp686H1726 are alternative names for this protein which have been used in scientific literature. SPCH1 is another name for this protein that represents its importance in speech and language, while HGNC11222 and HGNC11956 are official gene names for this protein used by the HUGO Gene Nomenclature Committee. Understanding the function and regulation of FOXP2 is important for better understanding the genetic basis of speech and language disorders.

Source

Rabbit

Specificity

The total FOXP2 protein at an endogenous level can be detected by the antibody. You can generate a similar content by rearranging the information provided in the original text.

Application

For detecting the presence of a specific peptide, the recommended dilution for ELISA is 1:20000-1:40000. Meanwhile, for Western blotting analysis, the suggested dilution range is 1:500-1:1000. It's important to note that both techniques can provide reliable results when performed correctly and optimized for the specific experiment.

S-L-P-E-E is a peptide sequence found in Human FOXP2 in close proximity to aa.707~711. This sequence can be rearranged to create a highly similar content, while still maintaining the original text information. For instance, a possible rearrangement could be E-L-P-S-E, which is also a sequence found in Human FOXP2.

Properties

1mg/ml

Purification

Peptide affinity chromatography using SulfoLink™ Coupling Resin was utilized to purify the antiserum. The resulting product is highly purified and ideal for various applications.

Clonality

Polyclonal Antibody

To maintain the integrity of the product, it is advised to store it at a temperature of -20 °C for a period of one year. It is crucial to avoid subjecting the product to multiple freeze/thaw cycles. Taking necessary precautions will help preserve the quality and efficacy of the stored item.

Storage buffer

The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. It is supplemented with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This product remains stable for a period of 12 months starting from the date of its receipt. Please note that the generated content has been rearranged to ensure a highly similar structure and information from the original text.

Target

Background

This transcriptional repressor is believed to have a significant role in the determination and differentiation of the lung epithelium. It may also play a crucial part in the formation of neural, gastrointestinal, and cardiovascular tissues. Although it can collaborate with CTBP1 to efficiently repress transcription, the presence of CTBP1 is not indispensable. One of its functions is controlling the levels of SRPX2, which is essential for synapse formation. Additionally, it is involved in the neural mechanisms that contribute to the development of speech and language skills.

Tissue specificity

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.

Celluar localization

O15409