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Rabbit Anti-CES2 Polyclonal Antibody#abs140974

Rabbit Anti-CES2 Polyclonal Antibody#abs140974

Please note that the price mentioned above is only for your reference. For more detailed pricing information, kindly get in touch with our seller Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specificationDelivery timeUSD price

abs140974-50ug

1-2 Weeks

201.0

abs140974-100ug

1-2 Weeks

301.0

Please note that the price mentioned above is only for your reference. For more detailed pricing information, kindly get in touch with our seller Vecent.


Overview

catalog

abs140974
Other namesCarboxylesterase 2, also known as CES2, CE-2, or intestinal/liver carboxylesterase 2 is an enzyme found in the intestine and liver that plays a crucial role in drug metabolism and detoxification. It is also known as cocaine esterase due to its ability to rapidly clear cocaine from the body.
In addition to drug metabolism, carboxylesterase 2 is involved in the hydrolysis of various esters, including dietary fats and drugs such as aspirin. This enzyme is highly expressed in the small intestine and liver, where it breaks down dietary fats into absorbable components.
Carboxylesterase 2 is encoded by the CES2 gene and belongs to the serine hydrolase family of enzymes. It has been shown to have multiple isoforms, including CES2A1, which is highly expressed in the liver.
Due to its role in drug metabolism, carboxylesterase 2 is a potential target for drug development and drug delivery. It may also play a role in the development and progression of certain diseases, such as cancer. Further research is needed to fully understand the functions and clinical potential of this enzyme.
SourceRabbit
SpecificityThe presence of total CES2 at natural levels can be identified by utilizing the CES2 antibody. This antibody is able to differentiate between endogenous and exogenous levels of CES2.
Species ReactivityHuman;Mouse
AntigenCES2
ApplicationFor Western blotting, it is recommended to use a dilution factor of 1:500 to 1:1000. In immunohistochemistry, a dilution of 1:50 to 1:200 is recommended. For immunofluorescence and immunocytochemistry, it is recommended to use a dilution of 1:100 to 1:500. For ELISA using a peptide as the antigen, a dilution factor of 1:20000 to 1:40000 is recommended. In summary, different dilution factors should be used depending on the specific experimental conditions for the most optimal results.
ImmunogenA synthesized peptide.
MW62 KD
Properties

Concentration

1mg/ml

purificationThe SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through the method of peptide affinity chromatography. The resulting product was highly purified to ensure its effectiveness.
ClonalityPolyclonal Antibody
Stability & StorageOne year of storage is recommended at a temperature of -20°C. To maintain the quality, it's essential to avoid exposing the product to repeated freeze/thaw cycles.
Storage bufferThe storage conditions for Rabbit IgG include keeping it in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended temperature for storage is at -20°C and it is stable for up to 12 months from the date of receipt. It is important to follow the recommended storage conditions to maintain the integrity of the product.

Target

Background

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Tissue specificityPreferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Posttranslational modificationGlycosylated.
Celluar localizationEndoplasmic reticulum;
UniPortO00748


This product is for research use only, not for use in diagnostic prodecures or in human.


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