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Rabbit Anti-CBR3 Polyclonal Antibody#abs140973

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Description

Catalog-specification	Delivery time	USD price
abs140973-100ug	1-2 Weeks	301.0
abs140973-50ug	1-2 Weeks	201.0

Overview
catalog	abs140973
Other names	NADPH-dependent carbonyl reductase 3, also known as CBR3 or short chain dehydrogenase/reductase family 21C member 2, is an enzyme with the EC number of 1.1.1.184. It plays a critical role in reducing carbonyl compounds using NADPH as the electron donor. In humans, CBR3 is expressed in several tissues including the epididymis, liver, and prostate. It has also been identified as a potential target for various diseases such as cancer and diabetes. CBR3 is also known as epididymis secretory protein Li 25 or HEL S 25. It is involved in the metabolism of various endogenous compounds such as prostaglandins and steroid hormones. Additionally, CBR3 is known to metabolize drugs such as daunorubicin and anthracyclines, which are commonly used in cancer chemotherapy. In summary, CBR3 is a crucial enzyme involved in the reduction of carbonyl compounds, which are important in the metabolism of endogenous compounds and drugs. Its overexpression or dysfunction has been linked to various diseases and makes it a potential therapeutic target.
Source	Rabbit
Specificity	The endogenous levels of total CBR3 can be accurately detected using the CBR3 Antibody. A highly similar content can be generated by reorganizing the original text information.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Dog
Antigen	CBR3
Application	For Western Blotting, dilute the antibody at a ratio of 1:500 to 1:1000. For Immunohistochemistry, a dilution of 1:50 to 1:200 is appropriate. For Immunofluorescence and Immunocytochemistry, a dilution of 1:100 to 1:500 is recommended. When performing ELISA with a peptide substrate, dilute the antibody at a ratio of 1:20000 to 1:40000 for optimal results. It is important to follow the recommended dilution guidelines to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	31 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™。
Clonality	Polyclonal Antibody
Stability & Storage	To keep the product in good condition, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this can cause the product to degrade over time. By following these storage recommendations, you can ensure that the product remains viable and effective for its intended use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).
Tissue specificity	Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	O75828