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Rabbit Anti-Nicalin Polyclonal Antibody#abs140484

Description

Catalog-specification	Delivery time	USD price
abs140484-100ug	1-2 Weeks	301.0
abs140484-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140484
Other names	NCLN, also known as Nicalin or NET59, is a protein that is highly similar to a protein found in zebrafish called Nicalin homolog. NCLN is also sometimes referred to as Nicastrin-like protein due to its close resemblance to another protein called Nicastrin. This protein plays an important role in various cellular processes and is a promising target for therapeutic interventions in certain diseases. Its exact function is still being studied by scientists, but its potential significance is becoming increasingly apparent with ongoing research efforts.
Source	Rabbit
Specificity	Endogenous levels of total Nicalin can be reliably detected using the Nicalin Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	Nicalin
Application	The dilution ratio for Western blotting (WB) is 1:1000. For immunofluorescence (IF) and immunocytochemistry (ICC), the recommended dilution range is 1:100-1:500. When performing ELISA using a peptide, a dilution of 1:20000-1:40000 is suggested.
Immunogen	A synthesized peptide derived from human Nicalin.
MW	63kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain stability, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to note that repeatedly subjecting the product to freeze and thaw cycles should be avoided.
Storage buffer	The Rabbit IgG solution is formulated in a phosphate buffered saline with pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% glycerol. The ideal storage temperature is at -20°C, and it remains stable for 12 months from the date of receipt, ensuring product efficacy.
Target
Background	May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Tissue specificity	Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
Celluar localization	Endoplasmic reticulum;
UniPort	Q969V3