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Rabbit Anti-JHD3D Polyclonal Antibody#abs132790

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Description

Catalog-specification	Delivery time	USD price
abs132790-100ug	1-2 Weeks	301.0
abs132790-50ug	1-2 Weeks	201.0

Overview
catalog	abs132790
Description	This enzyme is known as a histone demethylase that specifically targets the 'Lys-9' methylation mark on histone H3. Its role in the intricate histone code is pivotal. It does not remove methyl groups from other locations such as H3 'Lys-4', H3 'Lys-27', H3 'Lys-36', or H4 'Lys-20'. This demethylase is effective at removing both di- and trimethylation marks on the H3 'Lys-9' residue but does not act on monomethylated residues. Worth noting is that the process of demethylation releases formaldehyde and succinate as byproducts.
Other names	KDM4D, also known as JHDM3D or JmjC domain-containing histone demethylation protein 3D, is a lysine-specific demethylase that belongs to the Jumonji domain-containing protein 2D family. This protein plays an essential role in histone demethylation, specifically targeting lysine residues. Through its JmjC domain, KDM4D is able to remove methyl groups from histone proteins, thereby regulating gene expression and chromatin dynamics. KDM4D is a crucial player in various biological processes, including development, differentiation, and disease progression. Its unique structure and enzymatic activity make it an intriguing target for therapeutic interventions aimed at modulating specific gene expression patterns. Research on KDM4D continues to unravel its precise functions and potential therapeutic applications in various physiological and pathological contexts.
Source	Rabbit
Specificity	The JHD3D antibody is capable of detecting the natural levels of total JHD3D protein expression within cells. A closely resembling content can be produced by rearranging the provided information.
Species Reactivity	Human;Rat
Predictive reaction species	Dog
Antigen	JHD3D
Application	The dilution ratios for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) they range from 1:50 to 1:200, and for ELISA (peptide) they range from 1:20000 to 1:40000. These dilution ratios are used to ensure optimal performance of these experimental techniques.
Immunogen	A synthesized peptide.
MW	52 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used to purify the antiserum through peptide affinity chromatography. This process resulted in a highly refined and purified antiserum that is now available for further analysis and research. The selected resin is known for its effectiveness in coupling and purification procedures, making it a reliable choice for this application. The purified antiserum may prove useful in a variety of diagnostic and therapeutic applications, and its purity and quality have been confirmed through rigorous testing and analysis.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	Q6B0I6