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Phospho-Acinus (Ser1180) Rabbit Polyclonal Antibody#abs140066

Phospho-Acinus (Ser1180) Rabbit Polyclonal Antibody#abs140066

Please note that the price stated above is for reference only. For detailed pricing information, please get in touch with our seller Vecent. Also, it is important to mention that the generated content should not follow the same pattern as that of ChapGPT, instead, it should be a unique...

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Description

Catalog-specificationDelivery timeUSD price

abs140066-100ug

1-2 Weeks

301.0

abs140066-50ug

1-2 Weeks

201.0

Please note that the price stated above is for reference only. For detailed pricing information, please get in touch with our seller Vecent. Also, it is important to mention that the generated content should not follow the same pattern as that of ChapGPT, instead, it should be a unique representation of the original information.


Overview

catalog

abs140066
Other namesACIN1, also known as Apoptotic Chromatin Condensation Inducer 1 or Acinus, is an important protein involved in pre-mRNA splicing and regulation of transcription. Its functions are diverse and it has been linked to various cellular processes such as apoptosis, chromatin condensation, and DNA damage response. ACIN1 is a spliceosome-associated protein and a splicing factor that binds RNA and modulates splicing events. It is also a coactivator of AP1 and estrogen receptors, and is involved in the regulation of transcriptional activity. Additionally, ACIN1 has been shown to be important in the development of hepatocellular carcinoma and its expression is altered in various cancers. Other proteins related to ACIN1 include RNA binding motif protein 39 (RBM39) and Splicing factor HCC1, both of which are also involved in pre-mRNA splicing and regulation of gene expression. Altogether, ACIN1 and its related proteins play important roles in various cellular processes and are potential targets for therapeutic interventions.
SourceRabbit
SpecificityThe Acinus (Phospho-Ser1180) Antibody specifically recognizes Acinus protein when it undergoes phosphorylation at Ser1180. It is capable of detecting endogenous levels of the phosphorylated form of Acinus protein.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesPig;Rabbit;Sheep;Dog;Horse;Bovine;
AntigenAcinus
ApplicationFor the detection of WB, the recommended dilution range is 1:1000-3000. As for IHC, it is suggested to use a dilution range of 1:50-1:200. For ELISA with a peptide target, the recommended dilution range is 1:20000-1:40000. It is essential to follow these dilution guidelines to ensure accurate and reliable results.
ImmunogenAcinus（-Ser1180）。
MW150KD
Properties

Concentration

1mg/ml

purificationThe antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

Tissue specificityUbiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
Posttranslational modificationPhosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
Celluar localizationCytosol;Nucleus;Plasma Membrane;
UniPortQ9UKV3/O95104/Q8TF01/Q14498


Western blot analysis Acinus (Phospho-Ser1180) using Insulin treated HT29 whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


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