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Phospho-Connexin43 (Ser279) Rabbit Polyclonal Antibody#abs140057

Phospho-Connexin43 (Ser279) Rabbit Polyclonal Antibody#abs140057

Please note that the price mentioned above is only for your reference. For detailed pricing, please get in touch with our seller, Vecent. It's important to understand that the generated content may be similar in nature but will have a different structure and tone to the original text...

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Description

Catalog-specificationDelivery timeUSD price

abs140057-100ug

1-2 Weeks

301.0

abs140057-50ug

1-2 Weeks

201.0

Please note that the price mentioned above is only for your reference. For detailed pricing, please get in touch with our seller, Vecent. It's important to understand that the generated content may be similar in nature but will have a different structure and tone to the original text information. So, be mindful of this while communicating.


Overview

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abs140057
Other namesConnexin 43, also known as Cx 43 or Cx43, is a protein encoded by the CXA1_HUMAN gene. It is also referred to as Gap junction 43 kDa heart protein, Gap junction alpha-1 protein, or Gap junction protein alpha 1 43kDa (connexin 43). Additionally, it is sometimes called Gap junction protein alpha 1 43kDa, Gap junction protein alpha like, GJA 1, Gja1, GJAL, ODD, ODDD, ODOD, or SDTY3. This versatile protein plays a crucial role in forming gap junctions, which are intercellular channels that allow the direct exchange of small molecules and ions between adjacent cells. Connexin 43 is primarily found in the heart and is essential for the coordinated contraction of cardiac muscle cells. Mutations in the CXA1_HUMAN gene are associated with a genetic disorder called DFNB38, which causes hearing loss. It is fascinating how a single protein can have various names, reflecting its importance and multifunctionality in different biological contexts.
SourceRabbit
SpecificityThis antibody, Connexin 43 (Phospho-Ser279) Antibody, is specifically designed to detect endogenous levels of Connexin 43, which is only phosphorylated at Ser279. This means that it can only recognize Connexin 43 when it is in a phosphorylated state at that specific site.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesZebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
AntigenConnexin43
ApplicationWB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
ImmunogenA newly formulated peptide, created by combining different fragments of human Connexin 43 and phosphorylating Ser279, has been successfully synthesized. This synthesized peptide closely mimics the original protein and showcases its valuable characteristics.
MW43kDa
Properties

Concentration

1mg/ml

purificationThe highly purified antibody was obtained from rabbit serum by utilizing sequential chromatography on affinity columns specific to phospho- and non-phospho-peptides.
ClonalityPolyclonal Antibody
Stability & StorageTo ensure optimal storage conditions, it is advised to keep the item at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repetitive cycles of freezing and thawing.
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).

Tissue specificityExpressed in the heart and fetal cochlea.
Posttranslational modificationPhosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity).Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2.S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.
Celluar localizationEndoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Lysosome;Mitochondrion;Plasma Membrane;
UniPortP17302


Western blot analysis Connexin 43 (Phospho-Ser279) using PMA treated K562 whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


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