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Rabbit Anti-CLTR1 Polyclonal Antibody#abs131404

Rabbit Anti-CLTR1 Polyclonal Antibody#abs131404

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Description

Catalog-specificationDelivery timeUSD price

abs131404-50ug

1-2 Weeks

201.0

abs131404-100ug

1-2 Weeks

301.0

Please note that the price listed is for reference only. For accurate pricing information, please contact our seller Vecent. It's important to clarify that the price provided is not set in stone and is subject to change. For any questions or concerns, please don't hesitate to reach out to our sales team.


Overview

catalog

abs131404

Description

Individuals with and without asthma experience bronchoconstriction due to the activation of a specific receptor called the receptor for cysteinyl leukotrienes. When this receptor is stimulated by LTD4, it triggers various effects in the lungs, including the contraction and proliferation of smooth muscle, edema, migration of eosinophils, and damage to the protective mucus layer. These responses can contribute to respiratory distress and impaired lung function in affected individuals.

Other namesThe CysLT 1 receptor, also known as CYSLT 1, CYSLTR 1, or CysLTR, is a type of G-protein coupled receptor that plays a crucial role in the human body. This receptor binds to the cysteinyl leukotriene D4 and is responsible for mediating its effects on the body.
Variants of the CysLT 1 receptor are also referred to by other names, including CysLT(1), CYSLT1R, and LTD4 receptor. Additionally, the receptor is known by various other aliases, such as HG55, HMTMF81, and MGC46139.
Understanding the role of the CysLT 1 receptor is important for understanding the body's response to allergens and other types of inflammation. By targeting the receptor, scientists can design drugs that can help alleviate the symptoms of allergies and reduce the risk of other inflammatory diseases.
SourceRabbit
SpecificityThe CLTR1 Antibody is capable of detecting total CLTR1 levels which are present in an organism's body naturally. To create alternative content that conveys the same message, rearranging the phrases within the given text would be ideal. This assures the preservation of key information while also keeping it original.
Species ReactivityHuman;Mouse
AntigenCLTR1
ApplicationWB 1:500-1:2000，（IF）1:100-1:500，（ELISA）（）1:20000-1:40000。，。
ImmunogenA synthesized peptide derived from human CLTR1.
MW39 kDa
Properties

Concentration

1mg/ml

purificationUsing SulfoLink™ Coupling Resin, the purification of the antiserum involved peptide affinity chromatography.
ClonalityPolyclonal Antibody
Stability & StorageTo preserve the substance for a lengthy period, it should be kept at a temperature of -20 °C. To prevent damage to the substance, it is best to avoid exposing it to repeated freeze/thaw cycles. It is recommended to store it for one year under these conditions for maximum longevity. However, it's important to note that the substance may lose its efficiency if stored for an extended period.
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Tissue specificityWidely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Celluar localizationPlasma Membrane;
UniPortQ9Y271


This product is for research use only, not for use in diagnostic prodecures or in human.


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