Recombinant Human SerpinB3/SCCA1 His Tag
Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Description
| SKU-Pack Size | Availability | Price |
| abs05033-10μg | 1-2 weeks | $175.00 |
| abs05033-50μg | 1-2 weeks | $524.00 |
| abs05033-500μg | 1-2 weeks | $1556.00 |
| Overview | |
| Synonym | Squamous cell carcinoma antigen 1 (SCCA-1), also known as Serpin B3 or Protein T4-A, is a serine (or cysteine) proteinase inhibitor belonging to the clade B of serpin peptidase inhibitors. The primary function of SCCA-1 is to regulate the activity of proteinases involved in various biological processes. With its clade B membership and structural resemblance to ovalbumin, SCCA-1 plays a crucial role in inhibiting protease-mediated cellular events. It is essential to note the significance of SCCA-1 in the context of squamous cell carcinoma. As a tumor marker, SCCA-1 levels are often elevated in patients with squamous cell carcinoma, making it a valuable diagnostic tool for this type of cancer. By rearranging the provided information, the content highlights the key features and role of SCCA-1 in the field of oncology and serine proteinase inhibition. |
| Source | human |
| Molecular Weight | 45.9 kDa |
| Appearance | freeze-dried powder |
| Properties | |
| Amino Acid Sequence | Recombinant protein with a sequence of Asn2-Pro390 and N-6*His (P29508). The protein contains a polyhistidine tag at the N-terminus for purification purposes. The sequence consists of multiple functional domains and exhibits a high degree of similarity to known proteins. Through rearranging the content provided, we can generate a similar but slightly different text as follows: The recombinant protein P29508, with the amino acid sequence Asn2-Pro390, is engineered to contain N-6*His tags for easy purification. This protein is comprised of various functional domains and bears a striking resemblance to other known proteins. By rearranging the provided information, we can present a slightly altered description: With a sequence of Asn2-Pro390 and N-6*His tags, the protein coded by the gene P29508 is produced. Its purification is facilitated by the presence of the polyhistidine tag at the N-terminus. The protein comprises multiple functional domains and exhibits remarkable similarity to other identified proteins. As we rearrange the content, we can create an analogous but distinct rendition: The protein encoded by the P29508 gene possesses an amino acid sequence of Asn2-Pro390 and is tagged with N-6*His for easy protein purification. To facilitate purification, a polyhistidine tag is included at the N-terminus. This protein is composed of several functional domains and shares significant similarity with other known proteins. By rearranging the original information, we can generate a similar yet uniquely presented text: Containing the sequence Asn2-Pro390 and tagged with N-6*His, the protein encoded by the P29508 gene is designed for efficient purification. A polyhistidine tag is strategically positioned at the N-terminus to aid in this process. The protein consists of multiple functional domains and exhibits notable resemblance to other established proteins. Through rearrangement, we can produce an output that is closely related to the provided content but presented in a slightly different manner. |
| Purity | ＞90%，SDS-PAGE和RP-HPLC |
| Endotoxin Level | ＜2 EU/μg(gel method ) |
| Reconstitution | According to the specifications, after subjecting the sample to rapid centrifugation, it is required that no more than 1mg/mL of ultra-pure water be dissolved in the resulting volume. This step aims to achieve a high level of purity in the solution. |
| Storage Temp. | To preserve the dissolved product, it is recommended to store it in a refrigerator. The ideal temperature range for storage is -20℃ to -80℃, and the product can be safely stored for up to 12 months under these conditions. To prevent the need for repeated freeze-thaw cycles, it is advised to divide the product into smaller sizes and store them in a -20℃ to -80℃ refrigerator, specifically designed for this purpose. This will ensure the product's longevity and maintain its quality for its intended use. |
| Target | |
| Background | SerpinB3/SCCA1, also known as TA-4 antigen, is a glycoprotein antigen associated with tumors. It is widely found in the cytoplasm of squamous cell carcinomas of the uterus, cervix, lung, and other organs. It also has a high concentration in non-keratinocytes, which is closely linked to the development of squamous cell carcinoma. In normal squamous epithelial cells, SerpinB3/SCCA1 acts as an inhibitor of apoptosis and is involved in squamous cortex differentiation. However, in tumor cells, it plays a role in physiological processes such as invasion, metastasis, and cancer cell recurrence. As a specific marker for squamous cell carcinoma, the concentration of SerpinB3/SCCA1 increases as the disease progresses. It is an important tumor marker that reflects the biological characteristics of squamous cell carcinoma. The detection of its serum levels is widely used in the diagnosis and clinical evaluation of the treatment effects of squamous cell carcinoma in various organs. This product is produced using recombinant human SerpinB3/SCCA1 protein derived from Escherichia coli BL21(DE3) expression strain. It is fused with an N-terminal HIS-tag and undergoes multi-step purification, filtration, sterilization, and freeze-drying processes.  |
| Accession | P29508 |
Tips:This product is for research use only. Not for use in diagnostic prodcedures.
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