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Recombinant Human CD47 Fc Chimera

Experimental result diagram SDS PAGE The electrophoretic bands were marked as Marker, 2μg (NR non-reduction) and 2μg (R reduction). Tips:This product is for research use only. Not for use in diagnostic prodcedures.

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Description

SKU-Pack Size	Availability	Price
abs05025-25 μg	1-2 weeks	$127.00
abs05025-100 μg	1-2 weeks	$317.00

Overview
Synonym	Monoclonal 1D8 has identified an antigen, which is known as protein OA3 and bears an antigenic surface determinant. This antigen is also referred to as CD47 antigen or Rh-related antigen, and it serves as an integrin-associated signal transducer. CD47 antigen is a glycoprotein, and it is recognized by the leukocyte surface antigen CD47. Additionally, CD47 is also known as IAP or integrin-associated protein and is sometimes referred to as MER6. The protein MER6, which is synonymous with OA3, is another name for the CD47 molecule. Overall, this antigen, labeled with monoclonal 1D8, has various names such as CD47, IAP, MER6, integrin-associated protein, and Rh-related antigen.
Source	human
Molecular Weight	55~65 kDa(Reduced state)
Appearance	producing
Properties
Amino Acid Sequence	The protein sequence with C-hIgG Fc is Q08722, consisting of Gln19-Pro139. It contains various amino acids such as QLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK.
Purity	＞95% SDS-PAGE (Reduced state)
Endotoxin Level	＜0.1 EU/μg(Gel method)
Reconstitution	Following the rapid centrifugation process, an equivalent volume of ultrapure water was carefully measured as per the given specifications. This precise amount was then dissolved to obtain a concentration of 1mg/mL. To emphasize, it is important to generate a highly distinct content by reorganizing the provided information while still maintaining its essence.
Storage Temp.	，4°C1，2-4。-80℃-20℃，12。，。
General Notes	If you require a recombinant protein without any trehalose, please feel free to get in touch with us. We offer a product that consists of 5% trehalose content. Let us know your specific needs, and we will assist you accordingly.
Target
Background	CD47, also known as integrin-associated protein (IAP), serves as a quintessential representation of the "marker of self" found in all cell types. It is a glycoprotein that comprises an immunoglobulin-derived n-terminal domain, five transmembrane domains, and a concise C-terminal intracellular tail with four variable splicing isomers producing four distinct isoforms. A pivotal role of CD47 lies in the realm of targeted tumor immunotherapy. Cancer cells express CD47, which interacts with SIRPα and SIRPγ on NK cells to shield them from phagocytosis and subsequent elimination. In numerous solid tumor cells and malignant hematoma cells, CD47 demonstrates high expression levels, which positively correlate with the advancement of the disease. Let me know if you need further assistance!
Accession	Q08722