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Human CD23 / Fc Epsilon RII Protein

Description

SKU-Pack Size	Availability	Price
abs04920-100μg	1-2 weeks	$393.00
abs04920-500μg	1-2 weeks	$1310.00
abs04920-1mg	1-2 weeks	$2619.00

Overview
Synonym	CD23, also known as Fc-epsilon-RII or Immunoglobulin E-binding factor, is a C-type lectin domain protein encoded by the gene CLEC4J. It belongs to the C-type lectin domain family 4 member J and plays a critical role in regulating IgE levels and allergic responses. CD23 is expressed on B cells, macrophages, and dendritic cells and has two isoforms, CD23A and CD23B. CD23A is the IgE-binding form, while CD23B is a soluble form that can regulate IgE levels. CD23 is also known as FCE2 or IGEBF and is a key regulatory protein in the immune response.
Source	Human
Molecular Weight	According to the prediction, the protein's molecular weight is expected to be 31.8 kiloDaltons. However, due to glycosylation, it migrates to a higher range of 38-45 kDa as inferred from the Bis-Tris PAGE results. A careful analysis of this information indicates that the glycosylation process has a significant impact on the protein's physical and biochemical properties, which can further influence its biological function. Therefore, it is crucial to consider this modification when studying this protein in biological systems.
Form	The solution was filtered through a 0.22um filter and then lyophilized. Prior to lyophilization, a protectant of 5% trehalose was added to the solution. The solution was prepared in phosphate-buffered saline (PBS) with a pH of 7.4. Can you please generate a similar piece of text by reorganizing the given information?
Properties
Sequence	Asp48-Ser321
Purity	The level of purity for this sample was determined by two different methods, Bis-Tris PAGE and HPLC. Using Bis-Tris PAGE, the purity was found to be greater than 95%, while HPLC indicated that the purity was also greater than 95%. This demonstrates a high degree of consistency between the two analytical techniques, suggesting that the sample is of high quality and suitable for further analysis.
Endotoxin Level	Less than 1 EU per μg by the LAL method.
Storage Temp.	The product should be stored at -70℃ or -20℃.
Target
Background	CD23 serves as the low-affinity receptor for immunoglobulin (Ig)E, playing a critical role in regulating IgE responses. Additionally, CD23 is known to be shed from cell surfaces, resulting in the formation of a diverse range of soluble CD23 (sCD23) proteins, which possess various cytokine-like activities. These unique sCD23 proteins have pleiotropic functions, making them essential in several biological processes.
Accession	P06734-1

This particular product is exclusively intended for research purposes and is not intended for diagnostic procedures. It is important to thoroughly read and understand the indications for use before utilizing this product in any research setting. Please note that this product should never be used for diagnostic purposes, as it is not intended for such utilization. Therefore, researchers should use this product in strict adherence with the regulations governing their respective fields of research.

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