RUNX2 Polyclonal Antibody #abs116236

abs116236-50ul

In Stock

228

Other names

AML3;CBF-alpha-1;CBFA1;CCD;CCD1;CLCD;OSF-2;OSF2;PEA2aA;PEBP2aA

Source

Rabbit

Species Reactivity

Human;Mouse

Application

WB 1:200 - 1:1000

Immunogen

A fusion protein that incorporates a segment representing amino acids 242-521 of the human RUNX2 (NP_001019801.3) has been developed. This recombinant fusion protein is created by combining and reordering the specific amino acid sequence corresponding to human RUNX2. The resulting protein retains similarity to the original RUNX2 sequence while being incorporated into a new fusion protein construct.

Properties

U-251MG,K-562,Mouse thymus,Mouse spleen

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
The pH of the buffer is 7.3, and it contains 0.02% sodium azide and 50% glycerol. This formulation of PBS with sodium azide and glycerol is commonly used to preserve biological samples.

Target

Background

The Runt DNA-binding domain is present in this nuclear protein, which belongs to the RUNX family of transcription factors. It plays a crucial role in osteoblastic differentiation and the formation of the skeletal structure. Additionally, it serves as a scaffold for regulatory factors and nucleic acids involved in the expression of genes related to the skeletal system. This protein has the ability to bind DNA either as a monomer or as part of a heterodimeric complex, with a higher affinity in the latter form. The N-terminal region of the encoded protein contains two areas where trinucleotide repeat expansions may occur. Mutations in this gene, including those in the aforementioned areas, have been linked to cleidocranial dysplasia (CCD), a disorder affecting bone development. Various isoforms of the protein are produced due to alternate promoters and splicing events.

Celluar localization

Nucleus

UniPort

Q13950