UDB17 Antibody (Center) #abs110602

abs110602-50ul

In Stock

228

Description

Purified Rabbit Polyclonal Antibody (Pab)

Other names

UGT2B17, also known as UDP-glucuronosyltransferase 2B17 or C19-steroid-specific UDP-glucuronosyltransferase, is an enzyme that plays an important role in the metabolism of steroids in the human body. It belongs to the UDP glucuronosyltransferase family and is specifically involved in the glucuronidation of C19-steroids. This process is essential for the elimination of steroid hormones from the body, as it makes them more water-soluble and easier to excrete. UGT2B17 is also known for its ability to convert testosterone into its inactive form, which can have significant implications for hormone balance and body composition. Understanding the function of UGT2B17 is therefore crucial for the development of therapies for hormone-related conditions such as prostate cancer, breast cancer and polycystic ovary syndrome.

Source

Rabbit

Specificity

The generation of the UDB17 antibody involves immunizing rabbits with a synthetic peptide conjugated to KLH. This peptide is derived from the Central region of human UDB17 and spans amino acids 119-147. By using this method, a highly similar content can be produced, keeping in mind the original information provided.

Species Reactivity

Human

Application

WB~~1:1000
IHC-P~~1:10~50

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To maintain the refrigerated condition, keep it at 2-8°C for a maximum of 2 weeks. If you require long term storage, store it at -20°C in small aliquots to prevent freeze-thaw cycles.

Storage buffer

The antibody provided is a purified polyclonal antibody that comes in a PBS solution containing 0.09% (W/V) sodium azide. It is obtained through the process of Saturated Ammonium Sulfate (SAS) precipitation, followed by dialysis against PBS.

Research area

Signal Transduction

Target

Background

One of the critical enzymes in the breakdown of potentially harmful substances in the body is UDPGT. This isozyme plays a central role in the conjugation and subsequent elimination of both exogenous and endogenous compounds. Its chief substrates include eugenol, 4-methylumbelliferone, dihydrotestosterone (DHT), androstane-3-alpha,17-beta-diol (3-alpha-diol), testosterone and androsterone (ADT). The order of potency goes from eugenol, which is the most efficiently processed by UDPGT, through to ADT, which is the least efficiently conjugated. Overall, the UDPGT enzyme is a vital player in body metabolism and in the detoxification of many foreign compounds that could lead to cellular damage.

Celluar localization

The membrane of the microsome is composed of a single-pass membrane protein. Similarly, the endoplasmic reticulum membrane also contains a single-pass membrane protein. These proteins are crucial for the proper functioning of these organelles. They help in the transport of various substances across the membrane and maintain the structural integrity of the organelles. The intricate structure of these proteins allows for the specific recognition and binding of certain molecules, making them essential components of the cell membrane. Without them, the proper functioning of the cell would be compromised.

UniPort

O75795

References

References

Balliet,R.M., Cancer Res. 69 (7), 2981-2989 (2009)
Juul,A., J. Clin. Endocrinol. Metab. 94 (3), 1005-1011 (2009)