Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-UBR1 Polyclonal Antibody#abs141108

Please note that the price mentioned above serves as a reference only. In order to obtain detailed pricing information, please contact our representative, Vecent. To ensure accuracy, the content generated should be based on the original text provided, but produced in a manner that is distinct...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs141108-100ug	1-2 Weeks	301.0
abs141108-50ug	1-2 Weeks	201.0

Overview
catalog	abs141108
Other names	The protein known as UBR1, or JBS, functions as an E3 ubiquitin-protein ligase. It is also referred to as N-recognin-1 and ubiquitin protein ligase E3 component n-recognin 1, and is involved in the targeting and degradation of specific protein substrates. Additionally, this protein is sometimes referred to as Ubiquitin-protein ligase E3-alpha-1 or E3-alpha-I. UBR1 plays a critical role in regulating protein turnover within the cell, and serves as an important component of the ubiquitin-proteasome system. Understanding the function and regulation of UBR1 may have important implications for the treatment of a variety of diseases and disorders.
Source	Rabbit
Specificity	The UBR1 Antibody is capable of identifying total levels of endogenous UBR1 in a given sample. By detecting UBR1, this antibody can provide valuable insights into cellular processes in which UBR1 plays a role. It is important to note that this antibody detects total UBR1 and not just a specific isoform or fragment.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Xenopus;Sheep;Dog;Bovine;Horse;
Antigen	UBR1
Application	The dilutions for Western blot (WB) range from 1:500 to 1:1000, for immunofluorescence (IF) and immunocytochemistry (ICC) they range from 1:100 to 1:500, and for ELISA using peptide they range from 1:20000 to 1:40000. Please note that the generated content is expected to be highly similar to the original text information.
Immunogen	A synthesized peptide.
MW	36 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was utilized to purify the antiserum with the aid of SulfoLink™ Coupling Resin. The final outcome was a highly refined antiserum that was suitable for its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage is recommended at -20 °C. It is important to avoid freezing and thawing cycles repeatedly.
Storage buffer	Phosphate buffered saline, pH 7.4, containing rabbit IgG, 150mM NaCl, 0.02% sodium azide, and 50% glycerol can be stored at a temperature of -20 °C. This storage condition ensures its stability for a period of 12 months starting from the date of receipt.
Target
Background	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Tissue specificity	Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Celluar localization	Cytosol;
UniPort	Q8IWV7