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Rabbit Anti-IRF2 Polyclonal Antibody#abs133395

Description

Catalog-specification	Delivery time	USD price
abs133395-100ug	1-2 Weeks	301.0
abs133395-50ug	1-2 Weeks	201.0

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Overview
catalog	abs133395
Other names	DKFZp686F0244 is a gene that encodes for a protein called Interferon Regulatory Factor 2 (IRF-2). IRF-2 is a transcription factor that plays a critical role in regulating the expression of interferon genes. It is also involved in various biological processes, including immune response and cell growth regulation. IRF-2, also known as IRF2, is a crucial player in the immune system and has been extensively studied in humans. Understanding the functions and mechanisms of IRF-2 can provide valuable insights into the complex workings of the immune system and potentially lead to the development of new therapeutic strategies for immune-related disorders. Overall, DKFZp686F0244 and its encoded protein, IRF-2, hold great importance in our understanding of immune regulation and its implications in health and disease.
Source	Rabbit
Specificity	Endogenous levels of total IRF2 can be detected using the IRF2 Antibody. The antibody specifically targets and identifies the presence of IRF2 in the biological samples. By detecting the endogenous levels of IRF2, researchers can gain valuable insights into its expression and activity in various contexts. It provides a reliable tool for investigating the role of IRF2 in different biological processes and diseases.
Species Reactivity	Human;Mouse;Rat
Antigen	IRF2
Application	The dilutions for Western Blot (WB) range from 1:500 to 1:1000. For Immunohistochemistry (IHC), the recommended dilution is 1:50 to 1:200. In the case of Immunofluorescence/Immunocytochemistry (IF/ICC), the appropriate dilutions are 1:100 to 1:500. For ELISA (peptide), a dilution of 1:20000 to 1:40000 is recommended. Please note that the content generated is similar in meaning but presented in a rearranged manner to ensure accurate representation of the original information.
Immunogen	A synthesized peptide.
MW	47 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the item's quality, it is recommended to store it at -20 °C for a period of one year. It is crucial to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	This rabbit IgG solution is formulated with phosphate buffered saline at a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20°C and has a shelf life of 12 months from the date of receipt. This product is a reliable source of rabbit IgG and is perfect for various research applications.
Target
Background	This protein has a specific affinity for the interferon consensus sequence (ICS) found in the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. Through this binding, it effectively represses the expression of these genes. It also has an activating role for certain genes, including H4 and IL7. Constitutively binding to the ISRE promoter, it promotes the transcription of IL7. In terms of cell cycle regulation, it activates transcription during cell growth by binding to the site II (HiNF-M) promoter region of H4. Furthermore, it can counteract the transcriptional activation carried out by IRF1.
Tissue specificity	Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Posttranslational modification	Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
Celluar localization	Cytosol;Nucleus;
UniPort	P14316