Rabbit Anti-Collagen IV Alpha2 Polyclonal Antibody#abs131360
Please note that the price provided is for reference purposes only. For detailed pricing information, kindly get in touch with our seller, Vecent. It is important to reach out to Vecent to obtain accurate and up-to-date pricing details. This product is for research use only, not for use in...
Description
| Catalog-specification | Delivery time | USD price |
abs131360-50ug | 1-2 Weeks | 201.0 |
abs131360-100ug | 1-2 Weeks | 301.0 |
Please note that the price provided is for reference purposes only. For detailed pricing information, kindly get in touch with our seller, Vecent. It is important to reach out to Vecent to obtain accurate and up-to-date pricing details.
| Overview | |
catalog | abs131360 |
Description | hnRNP G is an important nucleic acid binding protein that plays crucial roles in various cellular processes such as DNA repair, telomere regulation, and transcriptional gene regulation. It also exhibits tumor suppressive activity, making it a valuable candidate for cancer research. Additionally, hnRNP G is believed to be involved in the splicing of pre-mRNA molecules, highlighting its significance in post-transcriptional gene regulation. |
| Other names | Collagen alpha 2(IV) chain, also known as COL4A2_HUMAN or Col4a2, is a protein called canstatin that belongs to the type IV collagen family. It plays a crucial role in the formation and maintenance of basement membranes, providing structural support to various tissues. Canstatin, derived from the alpha 2 chain of collagen type IV, possesses anti-angiogenic properties and inhibits the growth of blood vessels. This protein is vital for maintaining tissue integrity and has been implicated in various diseases and developmental disorders. Its significance in biological processes makes it an intriguing subject of study for researchers. |
| Source | Rabbit |
| Specificity | The detection of endogenous levels of total Collagen IV α2 can be achieved using the Collagen IV α2 Antibody. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | Collagen IV alpha2 |
| Application | The suggested dilutions for using the antibody applications are as follows: WB 1:500-1:2000, IHC 1:50-1:200, IF 1:100-1:500, and ELISA(peptide) 1:20000-1:40000. It is important to note that these dilutions may need to be optimized for individual experiments based on factors such as sample type and detection sensitivity. Therefore, it is recommended to perform a titration to determine the optimal antibody concentration for the specific application. Nonetheless, these dilutions are a great starting point for ensuring reliable and robust results in various antibody applications. |
| Immunogen | The α2 subunit of human Collagen IV serves as the source for the synthesis of a peptide. The resulting peptide is carefully designed to closely resemble the original protein structure. Creating a highly similar peptide involves rearranging and modifying the amino acid sequence of Collagen IV α2. This process ensures that the synthesized peptide exhibits similar properties and characteristics to its natural counterpart in human Collagen IV α2. |
| MW | 42 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. It underwent a rigorous process to ensure its high quality and effectiveness. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for up to one year. Avoid exposing it to repeated freeze/thaw cycles as this may affect its efficacy. Make sure to follow the storage instructions carefully to ensure the longevity of the product. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. |
| Posttranslational modification | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.Proteolytic processing produces the C-terminal NC1 peptide, canstatin. |
| Celluar localization | Endoplasmic reticulum;Extracellular region or secreted; |
| UniPort | P08572 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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