SAV1 Polyclonal Antibody #abs118753

abs118753-50ul

In Stock

228

Other names

SAV;WW45;WWP4

Source

Rabbit

Species Reactivity

Human,Mouse

Application

WB 1:1000 - 1:4000

Immunogen

A fusion protein composed of a segment that matches amino acids 1-210 of the human SAV1 protein (NP_068590.1) has been produced. To create a similar text, the information provided can be rearranged into different sentence structures while retaining the same meaning.

Properties

HeLa,SKOV3,SW480

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
pH7.3, PBS containing 0.02% sodium azide and 50% glycerol is an excellent buffer solution. It is composed of glycerol and sodium azide, with a final concentration of 50% and 0.02%, respectively. The pH of this buffer solution is 7.3, which is optimal for various applications. Additionally, the addition of sodium azide helps to prevent microbial growth, ensuring the stability and longevity of the solution. With its unique composition and pH level, this buffer is widely used in various biochemical and molecular biology experiments.

Target

Background

Proteins containing WW domains are present in all eukaryotes and serve as crucial regulators in various cellular processes like protein degradation, transcription, and RNA splicing. The gene under consideration codes for a protein that possesses two WW domains, a SARAH domain, and a coiled-coil region. It exhibits widespread expression in adult tissues. This particular protein interacts with MST1 (mammalian sterile 20-like kinase 1) and facilitates MST1-triggered apoptosis. Furthermore, it has been observed to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1), reducing the anti-apoptotic effects exerted by HAX1. Studies conducted in both human and mouse models propose that this gene operates as a tumor suppressor. To reiterate, the rearranged content emphasizes the significance of WW domain-containing proteins in cellular regulation, focusing on the specific functions of the encoded protein and its involvement in apoptosis and tumor suppression.

Celluar localization

Cytoplasm,Nucleus

UniPort

Q9H4B6