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Rabbit Anti-LMAN1 Polyclonal Antibody#abs137937

Description

Catalog-specification	Delivery time	USD price
abs137937-100ug	1-2 Weeks	301.0
abs137937-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137937
Other names	Protein ERGIC-53, also known as Endoplasmic Reticulum Golgi Intermediate Compartment Protein 53 or ER-Golgi Intermediate Compartment 53 kDa Protein, is a critical component of the ER-Golgi transport system. It is also referred to as ERGIC53 or Intracellular Mannose-Specific Lectin MR60. This protein, encoded by the LMAN1 gene, plays a crucial role in the trafficking of glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It acts as a receptor that binds to specific carbohydrates, particularly mannose residues, on glycoproteins. Through this interaction, ERGIC-53 aids in the packaging and sorting of glycoproteins into transport vesicles for their journey from the ER to the Golgi complex. Additionally, ERGIC-53 is involved in the biogenesis of blood coagulation factors, as it forms a complex with MCFD2 (also known as F5F8D) to ensure the proper secretion of these factors. The ERGIC-53 protein is characterized by its lectin activity and its 53-kilodalton molecular weight. It has been found to be highly conserved across species, indicating its importance in cellular processes. In summary, ERGIC-53 is an intracellular lectin that functions as a key player in the transport of glycoproteins between the ER and Golgi compartments. Its role in the biogenesis of blood coagulation factors underscores its physiological significance.
Source	Rabbit
Specificity	LMAN1 Antibody is designed to specifically recognize and bind to endogenous levels of total LMAN1 protein. Its capability to detect and measure the total amount of LMAN1 makes it a valuable tool in various research applications. By targeting this protein, researchers can gain insights into its expression levels and localization in different biological systems. This antibody offers a reliable and sensitive method for studying LMAN1 and its functions in cellular processes.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Dog;
Antigen	LMAN1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human LMAN1.
MW	58 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly refined product was the end result of this process.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's quality, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles during this storage period.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Tissue specificity	Ubiquitous.
Posttranslational modification	The N-terminal may be partly blocked.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;
UniPort	P49257