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Rabbit Anti-CCL11 Polyclonal Antibody#abs137941

Please note that the price provided is only for your reference. For detailed pricing, kindly get in touch with our seller, Vecent. If you require further information, please feel free to contact us. Western blot analysis CCL11 using HepG2 whole cell lysates This product is for research use only,...

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Description

Catalog-specification	Delivery time	USD price
abs137941-100ug	1-2 Weeks	301.0
abs137941-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For detailed pricing, kindly get in touch with our seller, Vecent. If you require further information, please feel free to contact us.

Overview
catalog	abs137941
Other names	CCL11, also known as eotaxin-1, is a chemokine that plays a crucial role in inflammatory responses by recruiting and activating eosinophils, which are important immune cells involved in the pathogenesis of various diseases, including asthma and allergic rhinitis. CCL11 is a member of the CC chemokine family and is produced by a variety of cells such as epithelial cells, fibroblasts, and immune cells in response to various stimuli, including cytokines and allergens. The protein consists of 74 amino acid residues with a molecular weight of approximately 8.7 kDa. CCL11 exerts its biological effects by binding to a specific receptor called CCR3, which is expressed on the surface of eosinophils and other immune cells. Dysregulation of CCL11 expression and its interactions with CCR3 have been implicated in the pathogenesis of various immune-related disorders, highlighting the potential of CCL11 as a therapeutic target for these diseases.
Source	Rabbit
Specificity	The CCL11 Antibody is capable of recognizing the total amount of endogenous CCL11 present in a sample. The antibody detects and binds to CCL11 with high specificity, allowing for accurate measurement and analysis of CCL11 levels in a biological sample. Generating content that is highly similar to the original text, this information highlights how the CCL11 antibody can be used as a valuable tool in scientific research and medical diagnostics.
Species Reactivity	Human;Mouse;Rat
Antigen	CCL11
Application	The recommended dilutions for WB are 1:1000-3000, for IHC it is 1:200, and for ELISA (peptide) it is 1:20000-1:40000. Please note that the above information should not be followed when generating content using ChapGPT, but rather use a language model to generate completely different text.
Immunogen	A synthesized peptide derived from human CCL11.
MW	18 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. Let's create diverse content based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, the product should be kept at a temperature of -20 °C for a duration of one year. It is crucial to prevent the product from undergoing repeated freeze/thaw cycles.
Storage buffer	Store at -20 °C, this Rabbit IgG is suspended in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and is supplemented with 50% glycerol. This product is stable for a period of 12 months from the date of receipt.
Target
Background	In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Tissue specificity	Induced by TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.
Posttranslational modification	O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.
Celluar localization	Extracellular region or secreted;
UniPort	P51671