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Rabbit Anti-MYBBP1A Polyclonal Antibody#abs137945

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Description

Catalog-specification	Delivery time	USD price
abs137945-100ug	1-2 Weeks	301.0
abs137945-50ug	1-2 Weeks	201.0

Overview
catalog	abs137945
Other names	Myb-binding protein 1A, also known as nuclear protein P160 or PAP2, is an important protein involved in regulating various cellular processes. Its function is to bind to the Myb transcription factor and regulate gene expression. The protein is also known to interact with p53 and PAR, making it a critical component of cellular pathways that control cell growth and tumorigenesis. In addition to its role as a transcriptional regulator, Mybbp1a has been implicated in DNA repair and maintenance. It is a component of the BRCA1 complex, which is necessary for the proper functioning of the DNA damage response pathway. Mybbp1a is also involved in chromatin remodeling, facilitating the access of other proteins to DNA. The human gene for Mybbp1a is located on chromosome 17 and codes for a protein of 1462 amino acids. It has several isoforms, including p67MBP and p160MBP. Overall, the importance of Mybbp1a in cellular processes cannot be overstated, and its dysregulation has been implicated in various diseases, including cancer. Further research into the mechanisms underlying its function may lead to the development of novel therapeutic strategies targeting this important protein.
Source	Rabbit
Specificity	Total levels of endogenous MYBBP1A can be detected using the MYBBP1A Antibody. This antibody specifically binds to MYBBP1A and can accurately detect its presence within cells or tissues. It is important to note that this antibody detects total MYBBP1A levels, including both the active and inactive forms of the protein. With its high specificity and sensitivity, the MYBBP1A Antibody is a valuable tool for studying the role of MYBBP1A in various cellular processes.
Species Reactivity	Human;Mouse;Rat
Antigen	MYBBP1A
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MYBBP1A.
MW	149 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was utilized for the purification of the antiserum. To maintain the focus on the original text information, an altered speech pattern is employed rather than generating content using ChapGPT.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the product is stored at -20 °C for a duration of one year to maintain its quality. It is crucial to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	This is a description of Rabbit IgG that is suspended in a phosphate buffered saline solution. The pH level is 7.4 and the solution contains 150mM of NaCl, 0.02% of sodium azide and 50% of glycerol. This product must be stored at a temperature of -20 °C and it will remain stable for up to 12 months from the date of receipt.
Target
Background	May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.
Posttranslational modification	Citrullinated by PADI4.
Celluar localization	Nucleus;
UniPort	Q9BQG0