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Rabbit Anti-RERG Polyclonal Antibody#abs139331

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Description

Catalog-specification	Delivery time	USD price
abs139331-100ug	1-2 Weeks	301.0
abs139331-50ug	1-2 Weeks	201.0

Overview
catalog	abs139331
Other names	RAS-related and estrogen-regulated growth inhibitor (RERG), also known as MGC15754, is a protein that exhibits weak similarity to the N ras protein in humans. It functions as an inhibitor of growth, specifically regulated by estrogen. RERG plays a crucial role in modulating cell proliferation and is involved in Ras signaling pathways. Its precise mechanism of action is yet to be fully elucidated.
Source	Rabbit
Specificity	The RERG Antibody is capable of detecting the total levels of endogenous RERG protein present within a sample. To rephrase this content in a highly similar manner, one could say that the RERG Antibody is effective in identifying the overall amount of RERG protein naturally present in a given sample.
Species Reactivity	Human;Mouse
Antigen	RERG
Application	Some recommended dilution ratios for WB are 1:1000-3000, while for IHC, a ratio of 1:200 is recommended. If you are using ELISA with a peptide, a dilution ratio of 1:20000-1:40000 is suggested. It is important to remember to follow the recommended dilution ratios to ensure the best results in your experiments.
Immunogen	A synthesized peptide derived from human RERG.
MW	23 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure a highly pure output, the resin functioned in coupling the desired peptides and promoting their effective separation. The resulting antiserum was of a high quality and suitable for further use in research and experimentation.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to keep it stored at a temperature of -20°C for a duration of one year. It is important to avoid any instances of freezing and thawing as this may cause damage to the product. Ensuring that proper storage conditions are followed will help to maintain the effectiveness of the product for its intended use.
Storage buffer	The storage condition for Rabbit IgG is as follows: It should be stored at -20 °C in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the IgG is guaranteed for a period of 12 months starting from the date of receipt.
Target
Background	Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
Tissue specificity	Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.
Celluar localization	Cytosol;Nucleus;
UniPort	Q96A58