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Rabbit Anti-EPB41 Polyclonal Antibody#abs132628

Please note that the price provided above is only for reference purposes. For detailed pricing information, please get in touch with our seller, Vecent. It is essential to contact Vecent to obtain accurate pricing details. Western blot analysis of EPB41 expression in 293T cell lysate,The lane on...

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Description

Catalog-specification	Delivery time	USD price
abs132628-50ug	1-2 Weeks	201.0
abs132628-100ug	1-2 Weeks	301.0

Overview
catalog	abs132628
Description	Protein 4.1, an essential component of the erythrocyte membrane skeleton, assumes a critical function in maintaining the physical characteristics of the membrane, particularly its mechanical stability and deformability. Its main role revolves around the stabilization of the interaction between spectrin and actin, which is crucial for the overall structure and function of the membrane. Additionally, it facilitates the recruitment of DLG1 to the cell membranes, further contributing to the intricate processes occurring within erythrocytes.
Other names	EPB4.1, also known as Band 4.1 or Protein 4.1, is a gene that encodes for a protein called Erythrocyte Membrane Protein Band 4.1. This protein is primarily found in red blood cells and plays a crucial role in maintaining their shape and integrity. Mutations in the EPB4.1 gene have been identified as the cause of Elliptocytosis 1, a genetic disorder characterized by abnormally shaped red blood cells. This condition is often linked to the RH blood group. Erythrocyte Surface Protein Band 4.1, also referred to as E41P or P4.1, is another name for this protein. Understanding the function and genetic variations of EPB4.1 can provide insights into the development and management of conditions related to red blood cell abnormalities.
Source	Rabbit
Specificity	The EPB41 antibody is capable of detecting total EPB41 levels that are naturally present within an organism. This means that it can accurately identify the amount of endogenous EPB41 present in a given sample. Through this process, researchers are able to gain a deeper understanding of the role that EPB41 plays in biological processes. Overall, the EPB41 antibody is an important tool for investigating the ways in which this protein impacts living organisms.
Species Reactivity	Human;Mouse
Antigen	EPB41
Application	WB1:500-1:2000，IF/ICC1:100-1:500，ELISA(peptide)1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	97 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography to ensure its purity.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's integrity, it is advised to keep it stored at a temperature of -20 °C for a duration of a year. To maintain its quality, it is recommended to avoid any instances of repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Posttranslational modification	Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;Plasma Membrane;
UniPort	P11171