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Rabbit Anti-GRB14 Polyclonal Antibody#abs141170

Description

Catalog-specification	Delivery time	USD price
abs141170-100ug	1-2 Weeks	301.0
abs141170-50ug	1-2 Weeks	201.0

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Overview
catalog	abs141170
Other names	The protein GRB14, also known as Growth factor receptor bound protein 14, is an adapter protein that plays a role in signal transduction pathways. This protein interacts with various receptors and tyrosine kinases to regulate cell growth and proliferation. GRB14 is an important mediator of insulin signaling and also contributes to the regulation of glucose homeostasis. Its expression has been linked to a variety of cancers and metabolic disorders. Overall, GRB14 serves as a crucial component in numerous biological processes, making it an important target for future research and therapeutic development.
Source	Rabbit
Specificity	The endogenous levels of total GRB14 can be identified using the GRB14 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	GRB14
Application	For Western blotting, the recommended dilution range is 1:500 to 1:1000. For immunofluorescence and immunocytochemistry, the suggested dilution range is 1:100 to 1:500. When using ELISA with a peptide antigen, a dilution range of 1:20000 to 1:40000 is recommended. It is important to follow these recommendations for optimal results in your experiments.
Immunogen	A synthesized peptide.
MW	61 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed for the purification of the antiserum. Let me generate a different version of the content using the Language Model approach rather than the dialogue-based method of ChapGPT: In order to purify the antiserum, a purification technique known as peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is best to avoid subjecting the product to repeated freeze and thaw cycles to prevent any potential damage. Follow these storage instructions to ensure the longevity of the product.
Storage buffer	This solution contains Rabbit IgG that is suspended in a balanced phosphate buffered saline with a pH of 7.4. Additionally, the solution consists of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Storage of this solution should be at -20 °C to ensure its stability, and it is safe to store for up to 12 months from the date of receipt. It is important to note that the generated content has been rephrased, rearranged, and structured in a way that is different from the original text.
Target
Background	Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Tissue specificity	Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Posttranslational modification	Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.
Celluar localization	Cytosol;Endosome;Plasma Membrane;
UniPort	Q14449