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Rabbit Anti-RBM5 Polyclonal Antibody#abs133508

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Description

Catalog-specification	Delivery time	USD price
abs133508-100ug	1-2 Weeks	301.0
abs133508-50ug	1-2 Weeks	201.0

Overview
catalog	abs133508
Other names	Protein G15, also known as LUCA15, is a putative tumor suppressor. It is encoded by the FLJ39876 gene and is involved in renal carcinoma. LUCA15 is also referred to as RBM5, which stands for RNA binding motif protein 5. RBM5_HUMAN is the protein identifier for RBM5 in humans. Additionally, LUCA15 is associated with the renal carcinoma antigen NY REN 9 and is sometimes referred to as Renal carcinoma antigen NY-REN-9. The RNA binding motif protein 5 plays a role as an RNA-binding protein, and it has been identified as a potential tumor suppressor. In summary, LUCA15, also known as Protein G15 or RBM5, is a putative tumor suppressor and renal carcinoma antigen. It belongs to the RNA-binding motif protein family and is associated with the FLJ39876 gene.
Source	Rabbit
Specificity	The RBM5 Antibody is capable of recognizing and measuring the natural levels of total RBM5 found within an organism.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	RBM5
Application	The recommended dilution for WB is 1:500 to 1:1000, for IHC it is 1:50 to 1:200, for IF/ICC it is 1:100 to 1:500, and for ELISA (peptide) it is 1:20000 to 1:40000. To reiterate, when using this product for Western Blotting, it is recommended to dilute it between 1:500 and 1:1000; for Immunohistochemistry, the ideal dilution range is between 1:50 and 1:200; for Immunofluorescence/Immunocytochemistry, the recommended range is between 1:100 and 1:500; lastly, for ELISA using a peptide, it is suggested to dilute the product between 1:20000 and 1:40000.
Immunogen	A synthesized peptide.
MW	92 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The resulting product is highly pure and effective for its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	This solution contains Rabbit IgG suspended in a phosphate buffered saline at a pH of 7.4, supplemented with 150mM of NaCl and 0.02% of sodium azide, and 50% glycerol. It is recommended to store at -20 °C, and it is stable for approximately one year from the date of receipt.
Target
Background	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Tissue specificity	Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
Celluar localization	Nucleus;
UniPort	P52756